Team game results -- 2021 Cleveland Indians
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | Decision | Save | Versus | T |
| 4/8/2021 | | |  NYY | W | 5-3 | | Verlander | R | Verlander | Jimenez,J | Flaherty,J | R |
| 4/8/2021 | | @ |  Tex | L | 5-6 | 12 | Verlander | R | Lopez,Y | | Matz | L |
| 4/9/2021 | | | NYY | W | 9-5 | | Hendricks | R | Trivino | Jimenez,J | Bundy | R |
| 4/9/2021 | | @ | Tex | W | 2-1 | | Hendricks | R | Hendricks | Jimenez,J | Wacha | R |
| 4/10/2021 | | | NYY | W | 6-5 | 13 | Keller, Brad | R | Lovelady | | Minor | L |
| 4/10/2021 | | @ | Tex | W | 8-2 | | Keller, Brad | R | Keller, Brad | | Agrazal | R |
| 4/11/2021 | | | NYY | L | 3-7 | | Keller, Mitch | R | Keller, Mitch | | Lamet | R |
| 4/11/2021 | | @ | Tex | W | 8-4 | | Keller, Mitch | R | Keller, Mitch | | King | R |
| 4/12/2021 | | |  ChW | W | 6-5 | 11 | Woodruff | R | Gsellman | | Giolito | R |
| 4/12/2021 | | @ |  Det | W | 9-3 | | Woodruff | R | Whitley,K | | Webb,L | R |
| 4/13/2021 | | | ChW | W | 5-3 | | Verlander | R | Verlander | Jimenez,J | Puk | L |
| 4/13/2021 | | @ | Det | L | 1-13 | | Verlander | R | Verlander | | Happ,J.A. | L |
| 4/14/2021 | | | ChW | L | 3-4 | | Hendricks | R | Hendricks | | Ohtani | R |
| 4/14/2021 | | @ | Det | W | 7-1 | | Hendricks | R | Hendricks | | Duffy,D | L |
| 4/16/2021 | | |  Tor | W | 4-0 | | Keller, Brad | R | Keller, Brad | | Freeland | L |
| 4/16/2021 | | @ |  Min | L | 2-7 | | Keller, Brad | R | Keller, Brad | | Gallen | R |
| 4/17/2021 | | | Tor | W | 6-2 | | Keller, Mitch | R | Keller, Mitch | | Reid-Foley | R |
| 4/17/2021 | | @ | Min | L | 3-12 | | Keller, Mitch | R | Keller, Mitch | | Paddack | R |
| 4/18/2021 | | | Tor | W | 8-3 | | Verlander | R | Verlander | | Yamaguchi | R |
| 4/18/2021 | | @ | Min | L | 2-4 | | Woodruff | R | Woodruff | | Ray,R | L |
| 4/23/2021 | | |  NYM | L | 5-6 | | Hendricks | R | Hendricks | | Cueto | R |
| 4/24/2021 | | | NYM | L | 1-7 | | Keller, Brad | R | Keller, Brad | | Gray,S | R |
| 4/25/2021 | | | NYM | W | 9-5 | | Keller, Mitch | R | Keller, Mitch | | Tanaka | R |
| 4/27/2021 | | |  Phi | W | 8-7 | 11 | Verlander | R | Whitley,K | | Castillo,L | R |
| 4/28/2021 | | | Phi | L | 0-4 | | Woodruff | R | Woodruff | | Carrasco | R |
| 4/29/2021 | | | Phi | L | 3-10 | | Hendricks | R | Hendricks | | Chirinos,Y | R |
| 5/3/2021 | | |  KCR | W | 9-5 | | Hendricks | R | Moronta | Lovelady | Quintana,J | L |
| 5/3/2021 | | @ |  Was | W | 5-2 | | Verlander | R | Verlander | Jimenez,J | Barria | R |
| 5/4/2021 | | | KCR | W | 6-4 | | Keller, Brad | R | Keller, Brad | Cleavinger | Wilson,Bry | R |
| 5/4/2021 | | @ | Was | W | 7-1 | | Hendricks | R | Moronta | | McKay,B | L |
| 5/5/2021 | | | KCR | L | 1-8 | | Keller, Mitch | R | Lovelady | | Hudson,Dak | R |
| 5/5/2021 | | @ | Was | L | 4-5 | | Keller, Brad | R | Keller, Brad | | Pivetta | R |
| 5/6/2021 | | | KCR | W | 5-0 | | Verlander | R | Verlander | | Fried | L |
| 5/6/2021 | | @ | Was | W | 12-8 | | Keller, Mitch | R | Claudio | | Eflin | R |
| 5/7/2021 | | @ |  SFG | L | 8-10 | | Woodruff | R | Whitley,K | | Crowe | R |
| 5/8/2021 | | @ | SFG | W | 9-3 | | Verlander | R | Verlander | | Kay | L |
| 5/9/2021 | | @ | SFG | W | 3-2 | | Hendricks | R | Hendricks | Jimenez,J | Garcia,Dei | R |
| 5/11/2021 | | @ |  LAD | L | 3-6 | | Keller, Brad | R | Keller, Brad | | Berrios | R |
| 5/12/2021 | | @ | LAD | W | 8-4 | | Keller, Mitch | R | Claudio | | Sanchez,S | R |
| 5/13/2021 | | @ | LAD | L | 2-5 | | Woodruff | R | Woodruff | | Musgrove | R |
| 5/24/2021 | | @ |  Mtl | W | 4-3 | | Verlander | R | Verlander | Jimenez,J | Yarbrough | L |
| 5/24/2021 | | |  LAA | W | 7-4 | | Keller, Brad | R | Whitley,K | Jimenez,J | Junis | R |
| 5/25/2021 | | @ | Mtl | W | 4-3 | | Hendricks | R | Hendricks | Jimenez,J | Dobnak | R |
| 5/25/2021 | | | LAA | L | 8-10 | 10 | Davidson,T | L | Trivino | | Williams,Tr | R |
| 5/26/2021 | | @ | Mtl | W | 4-3 | | Keller, Brad | R | Moronta | Jimenez,J | Bumgarner | L |
| 5/26/2021 | | | LAA | W | 4-3 | 10 | Verlander | R | Whitley,K | | Keuchel | L |
| 5/27/2021 | | @ | Mtl | W | 5-3 | | Davidson,T | L | Davidson,T | Moronta | Lopez,P | R |
| 5/27/2021 | | | LAA | L | 2-3 | | Hendricks | R | Trivino | | Pineda | R |
| 5/28/2021 | | @ | ChW | L | 3-4 | | Woodruff | R | Trivino | | Giolito | R |
| 5/28/2021 | | | Det | L | 3-7 | | Woodruff | R | Woodruff | | Webb,L | R |
| 5/29/2021 | | @ | ChW | W | 3-2 | 13 | Verlander | R | Whitley,K | Jimenez,J | Bassitt | R |
| 5/29/2021 | | | Det | L | 4-6 | | Keller, Brad | R | Jimenez,J | | Fulmer,M | R |
| 5/30/2021 | | @ | ChW | W | 10-1 | | Hendricks | R | Hendricks | | Chatwood | R |
| 5/30/2021 | | | Det | L | 4-13 | | Davidson,T | L | Davidson,T | | Sheffield,Ju | L |
| 6/1/2021 | | @ |  Bal | L | 3-4 | | Keller, Brad | R | Claudio | | Hill,R | L |
| 6/1/2021 | | | Tex | W | 10-3 | | Verlander | R | Verlander | | Matz | L |
| 6/2/2021 | | @ | Bal | L | 3-5 | | Davidson,T | L | Davidson,T | | Teheran | R |
| 6/2/2021 | | | Tex | W | 9-2 | | Hendricks | R | Hendricks | | Gomber | L |
| 6/3/2021 | | @ | Bal | W | 8-2 | | Woodruff | R | Woodruff | | Yamamoto | R |
| 6/3/2021 | | | Tex | W | 12-4 | | Woodruff | R | Woodruff | | Manaea | L |
| 6/4/2021 | | @ | Bal | W | 11-1 | | Verlander | R | Verlander | | German,D | R |
| 6/4/2021 | | | Tex | L | 0-5 | | Keller, Brad | R | Keller, Brad | | Agrazal | R |
| 6/8/2021 | | |  Mia | W | 3-2 | | Keller, Mitch | R | Claudio | Jimenez,J | Manning | R |
| 6/9/2021 | | | Mia | W | 6-5 | 10 | Verlander | R | Trivino | | Alcantara,Sa | R |
| 6/10/2021 | | | Mia | W | 5-1 | | Hendricks | R | Hendricks | | Arrieta | R |
| 6/11/2021 | | |  Pit | W | 8-2 | | Honeywell | R | Honeywell | Moronta | Morejon | L |
| 6/12/2021 | | | Pit | W | 6-2 | | Woodruff | R | Woodruff | | Allen,L | L |
| 6/13/2021 | | | Pit | W | 7-5 | | Keller, Mitch | R | Gsellman | Jimenez,J | Garcia,Ri | R |
| 6/15/2021 | | |  Atl | L | 2-7 | | Verlander | R | Verlander | | Santana,Er | R |
| 6/16/2021 | | | Atl | W | 5-4 | 11 | Hendricks | R | Jimenez,J | | Soroka | R |
| 6/17/2021 | | | Atl | W | 7-5 | | Honeywell | R | Trivino | | Singer,B | R |
| 6/18/2021 | | @ |  SDP | W | 11-4 | | Hendricks | R | Hendricks | | Maeda | R |
| 6/19/2021 | | @ | SDP | W | 4-3 | | Honeywell | R | Honeywell | Jimenez,J | Scherzer | R |
| 6/20/2021 | | @ | SDP | W | 11-1 | | Woodruff | R | Woodruff | | Nola,Aa | R |
| 6/22/2021 | | @ |  Col | W | 6-5 | | Keller, Mitch | R | Gsellman | Jimenez,J | Morton | R |
| 6/23/2021 | | @ | Col | L | 5-6 | | Verlander | R | Lovelady | | Ponce De Leon | R |
| 6/24/2021 | | @ | Col | W | 5-4 | | Hendricks | R | Hendricks | Jimenez,J | Lockett | R |
| 6/25/2021 | | @ |  Ari | L | 3-16 | | Honeywell | R | Honeywell | | Canning | R |
| 6/26/2021 | | @ | Ari | W | 5-4 | | Woodruff | R | Woodruff | Jimenez,J | Strasburg | R |
| 6/27/2021 | | @ | Ari | W | 10-1 | | Keller, Mitch | R | Keller, Mitch | | Lynn | R |
| 7/15/2021 | | | Mtl | W | 5-3 | | Honeywell | R | Honeywell | Jimenez,J | Bumgarner | L |
| 7/15/2021 | | @ | KCR | W | 4-2 | | Honeywell | R | Honeywell | Jimenez,J | Fried | L |
| 7/16/2021 | | | Mtl | W | 9-0 | | Hendricks | R | Hendricks | | Lopez,P | R |
| 7/16/2021 | | @ | KCR | W | 12-5 | | Hendricks | R | Hendricks | | Quintana,J | L |
| 7/17/2021 | | | Mtl | W | 3-2 | | Keller, Mitch | R | Keller, Mitch | Jimenez,J | Dobnak | R |
| 7/17/2021 | | @ | KCR | L | 1-2 | | Keller, Brad | R | Lovelady | | Davies | R |
| 7/18/2021 | | | Mtl | L | 1-3 | | Woodruff | R | Woodruff | | Yarbrough | L |
| 7/18/2021 | | @ | KCR | W | 8-2 | | Keller, Mitch | R | Keller, Mitch | | Hudson,Dak | R |
| 7/19/2021 | | @ | Tor | W | 13-8 | | Woodruff | R | Trivino | Jimenez,J | Freeland | L |
| 7/19/2021 | | | Min | W | 7-6 | | Keller, Brad | R | Whitley,K | | Rasmussen | R |
| 7/20/2021 | | @ | Tor | L | 3-6 | | Honeywell | R | Honeywell | | Lambert,P | R |
| 7/20/2021 | | | Min | L | 2-4 | | Honeywell | R | Honeywell | | Paddack | R |
| 7/21/2021 | | @ | Tor | W | 4-2 | | Hendricks | R | Hendricks | Jimenez,J | Supak | R |
| 7/21/2021 | | | Min | W | 4-0 | | Hendricks | R | Hendricks | | Gallen | R |
| 7/23/2021 | | | Bal | W | 5-2 | | Woodruff | R | Woodruff | Jimenez,J | Teheran | R |
| 7/23/2021 | | @ |  Sea | L | 0-2 | | Keller, Brad | R | Keller, Brad | | Samardzija | R |
| 7/24/2021 | | | Bal | W | 5-4 | | Keller, Mitch | R | Keller, Mitch | Cleavinger | Roark | R |
| 7/24/2021 | | @ | Sea | W | 9-4 | | Keller, Mitch | R | Lovelady | Claudio | Leake | R |
| 7/25/2021 | | | Bal | L | 1-5 | | Honeywell | R | Honeywell | | German,D | R |
| 7/25/2021 | | @ | Sea | L | 1-3 | | Woodruff | R | Whitley,K | | Dunn,J | R |
| 7/26/2021 | | | Bal | L | 4-12 | | Keller, Brad | R | Keller, Brad | | Yamamoto | R |
| 7/26/2021 | | @ | Sea | W | 5-2 | | Honeywell | R | Honeywell | Jimenez,J | Gonzales | L |
| 8/6/2021 | | | Tor | W | 5-1 | | Honeywell | R | Honeywell | | Lambert,P | R |
| 8/6/2021 | | @ | Min | W | 6-2 | | Verlander | R | Verlander | | Rasmussen | R |
| 8/7/2021 | | | Tor | L | 4-5 | | Woodruff | R | Trivino | | Freeland | L |
| 8/7/2021 | | @ | Min | L | 4-9 | | Keller, Brad | R | Keller, Brad | | Gallen | R |
| 8/8/2021 | | | Tor | L | 7-8 | | Verlander | R | Claudio | | Supak | R |
| 8/8/2021 | | @ | Min | L | 1-8 | | Woodruff | R | Woodruff | | Paddack | R |
| 8/9/2021 | | | ChW | W | 4-2 | | Keller, Brad | R | Keller, Brad | Trivino | Bassitt | R |
| 8/9/2021 | | @ | Det | L | 7-11 | | Keller, Mitch | R | Keller, Mitch | | Rogers,Tr | L |
| 8/10/2021 | | | ChW | W | 8-4 | | Keller, Mitch | R | Keller, Mitch | | Giolito | R |
| 8/10/2021 | | @ | Det | L | 3-7 | | Honeywell | R | Honeywell | | Duffy,D | L |
| 8/11/2021 | | | ChW | L | 2-5 | | Honeywell | R | Honeywell | | Wood,A | L |
| 8/11/2021 | | @ | Det | W | 8-5 | | Verlander | R | Verlander | Lopez,Y | Perez,Ma | L |
| 8/13/2021 | | @ |  Bos | W | 3-1 | 17 | Keller, Brad | R | Gsellman | Lopez,Y | Smeltzer | L |
| 8/13/2021 | | |  Oak | W | 5-3 | | Verlander | R | Verlander | Trivino | Hamels | L |
| 8/14/2021 | | @ | Bos | W | 7-1 | | Woodruff | R | Woodruff | | Bettis | R |
| 8/14/2021 | | | Oak | L | 1-5 | | Keller, Brad | R | Gsellman | | Wainwright | R |
| 8/15/2021 | | @ | Bos | L | 1-7 | | Keller, Mitch | R | Keller, Mitch | | Blach | L |
| 8/15/2021 | | | Oak | W | 7-6 | | Keller, Mitch | R | Whitley,K | | Abreu,B | R |
| 8/16/2021 | | @ | Bos | W | 7-6 | | Honeywell | R | Honeywell | Claudio | Clarke | R |
| 8/16/2021 | | | Oak | L | 4-8 | | Honeywell | R | Honeywell | | Quantrill | R |
| 8/23/2021 | | | Bos | L | 2-3 | 10 | Verlander | R | Jimenez,J | | Smeltzer | L |
| 8/23/2021 | | @ | Oak | W | 8-4 | | Keller, Brad | R | Keller, Brad | | Cole,G | R |
| 8/24/2021 | | | Bos | L | 6-8 | | Keller, Brad | R | Lovelady | | Bettis | R |
| 8/24/2021 | | @ | Oak | L | 4-5 | 12 | Verlander | R | Altavilla | | Cotton | R |
| 8/25/2021 | | | Bos | L | 4-7 | | Davidson,T | L | Davidson,T | | Margevicius | L |
| 8/25/2021 | | @ | Oak | W | 3-2 | | Hendricks | R | Hendricks | Jimenez,J | Eickhoff | R |
| 8/26/2021 | | | Bos | W | 10-5 | | Hendricks | R | Hendricks | | Clarke | R |
| 8/26/2021 | | @ | Oak | L | 2-5 | | Woodruff | R | Woodruff | | Walker,T | R |
| 8/27/2021 | | | Was | W | 5-3 | | Woodruff | R | Moronta | Jimenez,J | Luzardo | L |
| 8/27/2021 | | @ | LAA | L | 3-5 | | Davidson,T | L | Gsellman | | Junis | R |
| 8/28/2021 | | | Was | W | 8-6 | | Verlander | R | Verlander | Moronta | Barria | R |
| 8/28/2021 | | @ | LAA | W | 11-2 | | Keller, Brad | R | Keller, Brad | Altavilla | Pineda | R |
| 8/29/2021 | | | Was | W | 4-1 | | Keller, Brad | R | Moronta | Claudio | McKay,B | L |
| 8/29/2021 | | @ | LAA | W | 9-4 | | Verlander | R | Verlander | | Keuchel | L |
| 8/30/2021 | | | Was | W | 10-6 | | Davidson,T | L | Davidson,T | | Eflin | R |
| 8/30/2021 | | @ | LAA | W | 8-1 | | Hendricks | R | Hendricks | | Williams,Tr | R |
| 9/7/2021 | | @ | ChW | L | 4-5 | | Sulser,C | R | Moronta | | Porcello | R |
| 9/7/2021 | | | Det | W | 3-0 | | Hendricks | R | Hendricks | | Fulmer,M | R |
| 9/8/2021 | | @ | ChW | W | 3-1 | | Keller, Brad | R | Keller, Brad | Jimenez,J | Lester,Jon | L |
| 9/8/2021 | | | Det | L | 3-5 | | Verlander | R | Jimenez,J | | Rogers,Tr | L |
| 9/9/2021 | | @ | ChW | L | 0-14 | | Hendricks | R | Hendricks | | Ohtani | R |
| 9/9/2021 | | | Det | W | 3-0 | | Davidson,T | L | Davidson,T | | Beeks | L |
| 9/10/2021 | | @ | NYY | L | 1-2 | | Keller, Mitch | R | Keller, Mitch | | Lamet | R |
| 9/10/2021 | | | Sea | W | 13-2 | | Keller, Mitch | R | Keller, Mitch | Altavilla | Hernandez,F | R |
| 9/11/2021 | | @ | NYY | W | 9-4 | | Woodruff | R | Woodruff | | Flaherty,J | R |
| 9/11/2021 | | | Sea | L | 0-8 | | Keller, Brad | R | Keller, Brad | | Dunn,J | R |
| 9/12/2021 | | @ | NYY | L | 3-8 | | Davidson,T | L | Davidson,T | | Whitley,F | R |
| 9/12/2021 | | | Sea | W | 8-0 | | Hendricks | R | Hendricks | | Gonzales | L |
| 9/13/2021 | | @ | NYY | W | 5-4 | 11 | Keller, Brad | R | Trivino | Jimenez,J | Toussaint | R |
| 9/13/2021 | | | Sea | W | 10-3 | | Verlander | R | Verlander | | Canning | R |
| 9/24/2021 | | @ | Tor | W | 6-5 | | Hendricks | R | Hendricks | Jimenez,J | Merryweather | R |
| 9/24/2021 | | | Min | L | 5-6 | | Davidson,T | L | Davidson,T | | Rasmussen | R |
| 9/25/2021 | | @ | Tor | L | 9-10 | | Keller, Mitch | R | Trivino | | Supak | R |
| 9/25/2021 | | | Min | W | 3-2 | | Keller, Brad | R | Moronta | Jimenez,J | Paddack | R |
| 9/26/2021 | | @ | Tor | L | 6-7 | | Davidson,T | L | Lovelady | | Plutko | R |
| 9/26/2021 | | | Min | W | 5-4 | | Keller, Mitch | R | Lovelady | | Gallen | R |
| 9/27/2021 | | | Min | L | 4-6 | | Hendricks | R | Hendricks | | Turnbull | R |
| 9/27/2021 | | @ | Min | W | 9-6 | | Keller, Brad | R | Keller, Brad | Jimenez,J | Paddack | R |
| 9/28/2021 | | | Min | L | 3-5 | | Verlander | R | Verlander | | Lauer | L |
| 9/28/2021 | | @ | Min | W | 9-6 | | Verlander | R | Lopez,Y | Altavilla | Lauer | L |
| Other |
| Game information | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | | W | L | Pct | L10 | Strk | Gm# |
| 4/8/2021 | | | NYY | W | Encarnacion | 5 | 3 | | 1 | 0 | 1.000 | 1-0 | W1 | 1 |
| 4/8/2021 | | @ | Tex | L | | 5 | 6 | | 1 | 1 | .500 | 1-1 | L1 | 2 |
| 4/9/2021 | | | NYY | W | Kepler | 9 | 5 | | 2 | 1 | .667 | 2-1 | W1 | 3 |
| 4/9/2021 | | @ | Tex | W | Gerber,M | 2 | 1 | | 3 | 1 | .750 | 3-1 | W2 | 4 |
| 4/10/2021 | | | NYY | W | Encarnacion | 6 | 5 | | 4 | 1 | .800 | 4-1 | W3 | 5 |
| 4/10/2021 | | @ | Tex | W | Correa | 8 | 2 | | 5 | 1 | .833 | 5-1 | W4 | 6 |
| 4/11/2021 | | | NYY | L | | 3 | 7 | | 5 | 2 | .714 | 5-2 | L1 | 7 |
| 4/11/2021 | | @ | Tex | W | Correa | 8 | 4 | | 6 | 2 | .750 | 6-2 | W1 | 8 |
| 4/12/2021 | | | ChW | W | Acuna Jr. | 6 | 5 | | 7 | 2 | .778 | 7-2 | W2 | 9 |
| 4/12/2021 | | @ | Det | W | | 9 | 3 | | 8 | 2 | .800 | 8-2 | W3 | 10 |
| 4/13/2021 | | | ChW | W | Torres,G | 5 | 3 | | 9 | 2 | .818 | 8-2 | W4 | 11 |
| 4/13/2021 | | @ | Det | L | | 1 | 13 | | 9 | 3 | .750 | 8-2 | L1 | 12 |
| 4/14/2021 | | | ChW | L | | 3 | 4 | | 9 | 4 | .692 | 7-3 | L2 | 13 |
| 4/14/2021 | | @ | Det | W | Anderson,Bri | 7 | 1 | | 10 | 4 | .714 | 7-3 | W1 | 14 |
| 4/16/2021 | | | Tor | W | Realmuto | 4 | 0 | | 11 | 4 | .733 | 7-3 | W2 | 15 |
| 4/16/2021 | | @ | Min | L | | 2 | 7 | | 11 | 5 | .688 | 6-4 | L1 | 16 |
| 4/17/2021 | | | Tor | W | Realmuto | 6 | 2 | | 12 | 5 | .706 | 7-3 | W1 | 17 |
| 4/17/2021 | | @ | Min | L | | 3 | 12 | | 12 | 6 | .667 | 6-4 | L1 | 18 |
| 4/18/2021 | | | Tor | W | Anderson,Bri | 8 | 3 | | 13 | 6 | .684 | 6-4 | W1 | 19 |
| 4/18/2021 | | @ | Min | L | | 2 | 4 | | 13 | 7 | .650 | 5-5 | L1 | 20 |
| 4/23/2021 | | | NYM | L | | 5 | 6 | | 13 | 8 | .619 | 4-6 | L2 | 21 |
| 4/24/2021 | | | NYM | L | | 1 | 7 | | 13 | 9 | .591 | 4-6 | L3 | 22 |
| 4/25/2021 | | | NYM | W | Kepler | 9 | 5 | | 14 | 9 | .609 | 5-5 | W1 | 23 |
| 4/27/2021 | | | Phi | W | Correa | 8 | 7 | | 15 | 9 | .625 | 5-5 | W2 | 24 |
| 4/28/2021 | | | Phi | L | | 0 | 4 | | 15 | 10 | .600 | 4-6 | L1 | 25 |
| 4/29/2021 | | | Phi | L | | 3 | 10 | | 15 | 11 | .577 | 4-6 | L2 | 26 |
| 5/3/2021 | | | KCR | W | | 9 | 5 | | 16 | 11 | .593 | 4-6 | W1 | 27 |
| 5/3/2021 | | @ | Was | W | Torres,G | 5 | 2 | | 17 | 11 | .607 | 5-5 | W2 | 28 |
| 5/4/2021 | | | KCR | W | Gerber,M | 6 | 4 | | 18 | 11 | .621 | 5-5 | W3 | 29 |
| 5/4/2021 | | @ | Was | W | Anderson,Bri | 7 | 1 | | 19 | 11 | .633 | 6-4 | W4 | 30 |
| 5/5/2021 | | | KCR | L | | 1 | 8 | | 19 | 12 | .613 | 6-4 | L1 | 31 |
| 5/5/2021 | | @ | Was | L | | 4 | 5 | | 19 | 13 | .594 | 6-4 | L2 | 32 |
| 5/6/2021 | | | KCR | W | Dietrich | 5 | 0 | | 20 | 13 | .606 | 6-4 | W1 | 33 |
| 5/6/2021 | | @ | Was | W | Kepler | 12 | 8 | | 21 | 13 | .618 | 6-4 | W2 | 34 |
| 5/7/2021 | | @ | SFG | L | | 8 | 10 | | 21 | 14 | .600 | 6-4 | L1 | 35 |
| 5/8/2021 | | @ | SFG | W | Correa | 9 | 3 | | 22 | 14 | .611 | 7-3 | W1 | 36 |
| 5/9/2021 | | @ | SFG | W | Torres,G | 3 | 2 | | 23 | 14 | .622 | 7-3 | W2 | 37 |
| 5/11/2021 | | @ | LAD | L | | 3 | 6 | | 23 | 15 | .605 | 6-4 | L1 | 38 |
| 5/12/2021 | | @ | LAD | W | Realmuto | 8 | 4 | | 24 | 15 | .615 | 6-4 | W1 | 39 |
| 5/13/2021 | | @ | LAD | L | | 2 | 5 | | 24 | 16 | .600 | 5-5 | L1 | 40 |
| 5/24/2021 | | @ | Mtl | W | Acuna Jr. | 4 | 3 | | 25 | 16 | .610 | 6-4 | W1 | 41 |
| 5/24/2021 | | | LAA | W | Gerber,M | 7 | 4 | | 26 | 16 | .619 | 7-3 | W2 | 42 |
| 5/25/2021 | | @ | Mtl | W | Acuna Jr. | 4 | 3 | | 27 | 16 | .628 | 7-3 | W3 | 43 |
| 5/25/2021 | | | LAA | L | | 8 | 10 | | 27 | 17 | .614 | 6-4 | L1 | 44 |
| 5/26/2021 | | @ | Mtl | W | Lamb | 4 | 3 | | 28 | 17 | .622 | 7-3 | W1 | 45 |
| 5/26/2021 | | | LAA | W | Gerber,M | 4 | 3 | | 29 | 17 | .630 | 7-3 | W2 | 46 |
| 5/27/2021 | | @ | Mtl | W | Acuna Jr. | 5 | 3 | | 30 | 17 | .638 | 7-3 | W3 | 47 |
| 5/27/2021 | | | LAA | L | | 2 | 3 | | 30 | 18 | .625 | 7-3 | L1 | 48 |
| 5/28/2021 | | @ | ChW | L | | 3 | 4 | | 30 | 19 | .612 | 6-4 | L2 | 49 |
| 5/28/2021 | | | Det | L | | 3 | 7 | | 30 | 20 | .600 | 6-4 | L3 | 50 |
| 5/29/2021 | | @ | ChW | W | Renfroe | 3 | 2 | | 31 | 20 | .608 | 6-4 | W1 | 51 |
| 5/29/2021 | | | Det | L | | 4 | 6 | | 31 | 21 | .596 | 5-5 | L1 | 52 |
| 5/30/2021 | | @ | ChW | W | Lamb | 10 | 1 | | 32 | 21 | .604 | 5-5 | W1 | 53 |
| 5/30/2021 | | | Det | L | | 4 | 13 | | 32 | 22 | .593 | 5-5 | L1 | 54 |
| 6/1/2021 | | @ | Bal | L | | 3 | 4 | | 32 | 23 | .582 | 4-6 | L2 | 55 |
| 6/1/2021 | | | Tex | W | Realmuto | 10 | 3 | | 33 | 23 | .589 | 4-6 | W1 | 56 |
| 6/2/2021 | | @ | Bal | L | | 3 | 5 | | 33 | 24 | .579 | 3-7 | L1 | 57 |
| 6/2/2021 | | | Tex | W | Renfroe | 9 | 2 | | 34 | 24 | .586 | 4-6 | W1 | 58 |
| 6/3/2021 | | @ | Bal | W | Dietrich | 8 | 2 | | 35 | 24 | .593 | 5-5 | W2 | 59 |
| 6/3/2021 | | | Tex | W | Realmuto | 12 | 4 | | 36 | 24 | .600 | 6-4 | W3 | 60 |
| 6/4/2021 | | @ | Bal | W | Acuna Jr. | 11 | 1 | | 37 | 24 | .607 | 6-4 | W4 | 61 |
| 6/4/2021 | | | Tex | L | | 0 | 5 | | 37 | 25 | .597 | 6-4 | L1 | 62 |
| 6/8/2021 | | | Mia | W | Realmuto | 3 | 2 | | 38 | 25 | .603 | 6-4 | W1 | 63 |
| 6/9/2021 | | | Mia | W | Contreras,WE | 6 | 5 | | 39 | 25 | .609 | 7-3 | W2 | 64 |
| 6/10/2021 | | | Mia | W | | 5 | 1 | | 40 | 25 | .615 | 8-2 | W3 | 65 |
| 6/11/2021 | | | Pit | W | | 8 | 2 | | 41 | 25 | .621 | 8-2 | W4 | 66 |
| 6/12/2021 | | | Pit | W | Realmuto | 6 | 2 | | 42 | 25 | .627 | 9-1 | W5 | 67 |
| 6/13/2021 | | | Pit | W | Lamb | 7 | 5 | | 43 | 25 | .632 | 9-1 | W6 | 68 |
| 6/15/2021 | | | Atl | L | | 2 | 7 | | 43 | 26 | .623 | 8-2 | L1 | 69 |
| 6/16/2021 | | | Atl | W | Anderson,Bri | 5 | 4 | | 44 | 26 | .629 | 8-2 | W1 | 70 |
| 6/17/2021 | | | Atl | W | Torres,G | 7 | 5 | | 45 | 26 | .634 | 8-2 | W2 | 71 |
| 6/18/2021 | | @ | SDP | W | Anderson,Bri | 11 | 4 | | 46 | 26 | .639 | 9-1 | W3 | 72 |
| 6/19/2021 | | @ | SDP | W | Torres,G | 4 | 3 | | 47 | 26 | .644 | 9-1 | W4 | 73 |
| 6/20/2021 | | @ | SDP | W | Kepler | 11 | 1 | | 48 | 26 | .649 | 9-1 | W5 | 74 |
| 6/22/2021 | | @ | Col | W | Anderson,Bri | 6 | 5 | | 49 | 26 | .653 | 9-1 | W6 | 75 |
| 6/23/2021 | | @ | Col | L | | 5 | 6 | | 49 | 27 | .645 | 8-2 | L1 | 76 |
| 6/24/2021 | | @ | Col | W | Realmuto | 5 | 4 | | 50 | 27 | .649 | 8-2 | W1 | 77 |
| 6/25/2021 | | @ | Ari | L | | 3 | 16 | | 50 | 28 | .641 | 7-3 | L1 | 78 |
| 6/26/2021 | | @ | Ari | W | Lamb | 5 | 4 | | 51 | 28 | .646 | 8-2 | W1 | 79 |
| 6/27/2021 | | @ | Ari | W | Gerber,M | 10 | 1 | | 52 | 28 | .650 | 8-2 | W2 | 80 |
| 7/15/2021 | | | Mtl | W | Anderson,Bri | 5 | 3 | | 53 | 28 | .654 | 8-2 | W3 | 81 |
| 7/15/2021 | | @ | KCR | W | Dietrich | 4 | 2 | | 54 | 28 | .659 | 8-2 | W4 | 82 |
| 7/16/2021 | | | Mtl | W | Acuna Jr. | 9 | 0 | | 55 | 28 | .663 | 8-2 | W5 | 83 |
| 7/16/2021 | | @ | KCR | W | Realmuto | 12 | 5 | | 56 | 28 | .667 | 8-2 | W6 | 84 |
| 7/17/2021 | | | Mtl | W | Torres,G | 3 | 2 | | 57 | 28 | .671 | 8-2 | W7 | 85 |
| 7/17/2021 | | @ | KCR | L | | 1 | 2 | | 57 | 29 | .663 | 8-2 | L1 | 86 |
| 7/18/2021 | | | Mtl | L | | 1 | 3 | | 57 | 30 | .655 | 7-3 | L2 | 87 |
| 7/18/2021 | | @ | KCR | W | Renfroe | 8 | 2 | | 58 | 30 | .659 | 8-2 | W1 | 88 |
| 7/19/2021 | | @ | Tor | W | Realmuto | 13 | 8 | | 59 | 30 | .663 | 8-2 | W2 | 89 |
| 7/19/2021 | | | Min | W | Torres,G | 7 | 6 | | 60 | 30 | .667 | 8-2 | W3 | 90 |
| 7/20/2021 | | @ | Tor | L | | 3 | 6 | | 60 | 31 | .659 | 7-3 | L1 | 91 |
| 7/20/2021 | | | Min | L | | 2 | 4 | | 60 | 32 | .652 | 6-4 | L2 | 92 |
| 7/21/2021 | | @ | Tor | W | Lamb | 4 | 2 | | 61 | 32 | .656 | 6-4 | W1 | 93 |
| 7/21/2021 | | | Min | W | Miller,Bra | 4 | 0 | | 62 | 32 | .660 | 6-4 | W2 | 94 |
| 7/23/2021 | | | Bal | W | Kepler | 5 | 2 | | 63 | 32 | .663 | 6-4 | W3 | 95 |
| 7/23/2021 | | @ | Sea | L | | 0 | 2 | | 63 | 33 | .656 | 6-4 | L1 | 96 |
| 7/24/2021 | | | Bal | W | Realmuto | 5 | 4 | | 64 | 33 | .660 | 7-3 | W1 | 97 |
| 7/24/2021 | | @ | Sea | W | Torres,G | 9 | 4 | | 65 | 33 | .663 | 7-3 | W2 | 98 |
| 7/25/2021 | | | Bal | L | | 1 | 5 | | 65 | 34 | .657 | 6-4 | L1 | 99 |
| 7/25/2021 | | @ | Sea | L | | 1 | 3 | | 65 | 35 | .650 | 5-5 | L2 | 100 |
| 7/26/2021 | | | Bal | L | | 4 | 12 | | 65 | 36 | .644 | 5-5 | L3 | 101 |
| 7/26/2021 | | @ | Sea | W | Torres,G | 5 | 2 | | 66 | 36 | .647 | 6-4 | W1 | 102 |
| 8/6/2021 | | | Tor | W | Correa | 5 | 1 | | 67 | 36 | .650 | 6-4 | W2 | 103 |
| 8/6/2021 | | @ | Min | W | Realmuto | 6 | 2 | | 68 | 36 | .654 | 6-4 | W3 | 104 |
| 8/7/2021 | | | Tor | L | | 4 | 5 | | 68 | 37 | .648 | 5-5 | L1 | 105 |
| 8/7/2021 | | @ | Min | L | | 4 | 9 | | 68 | 38 | .642 | 5-5 | L2 | 106 |
| 8/8/2021 | | | Tor | L | | 7 | 8 | | 68 | 39 | .636 | 4-6 | L3 | 107 |
| 8/8/2021 | | @ | Min | L | | 1 | 8 | | 68 | 40 | .630 | 3-7 | L4 | 108 |
| 8/9/2021 | | | ChW | W | Realmuto | 4 | 2 | | 69 | 40 | .633 | 4-6 | W1 | 109 |
| 8/9/2021 | | @ | Det | L | | 7 | 11 | | 69 | 41 | .627 | 4-6 | L1 | 110 |
| 8/10/2021 | | | ChW | W | Lamb | 8 | 4 | | 70 | 41 | .631 | 5-5 | W1 | 111 |
| 8/10/2021 | | @ | Det | L | | 3 | 7 | | 70 | 42 | .625 | 4-6 | L1 | 112 |
| 8/11/2021 | | | ChW | L | | 2 | 5 | | 70 | 43 | .619 | 3-7 | L2 | 113 |
| 8/11/2021 | | @ | Det | W | Realmuto | 8 | 5 | | 71 | 43 | .623 | 3-7 | W1 | 114 |
| 8/13/2021 | | @ | Bos | W | Correa | 3 | 1 | | 72 | 43 | .626 | 4-6 | W2 | 115 |
| 8/13/2021 | | | Oak | W | Realmuto | 5 | 3 | | 73 | 43 | .629 | 5-5 | W3 | 116 |
| 8/14/2021 | | @ | Bos | W | Torres,G | 7 | 1 | | 74 | 43 | .632 | 6-4 | W4 | 117 |
| 8/14/2021 | | | Oak | L | | 1 | 5 | | 74 | 44 | .627 | 6-4 | L1 | 118 |
| 8/15/2021 | | @ | Bos | L | | 1 | 7 | | 74 | 45 | .622 | 5-5 | L2 | 119 |
| 8/15/2021 | | | Oak | W | Kepler | 7 | 6 | | 75 | 45 | .625 | 6-4 | W1 | 120 |
| 8/16/2021 | | @ | Bos | W | Acuna Jr. | 7 | 6 | | 76 | 45 | .628 | 6-4 | W2 | 121 |
| 8/16/2021 | | | Oak | L | | 4 | 8 | | 76 | 46 | .623 | 6-4 | L1 | 122 |
| 8/23/2021 | | | Bos | L | | 2 | 3 | | 76 | 47 | .618 | 6-4 | L2 | 123 |
| 8/23/2021 | | @ | Oak | W | Lamb | 8 | 4 | | 77 | 47 | .621 | 6-4 | W1 | 124 |
| 8/24/2021 | | | Bos | L | | 6 | 8 | | 77 | 48 | .616 | 5-5 | L1 | 125 |
| 8/24/2021 | | @ | Oak | L | | 4 | 5 | | 77 | 49 | .611 | 4-6 | L2 | 126 |
| 8/25/2021 | | | Bos | L | | 4 | 7 | | 77 | 50 | .606 | 3-7 | L3 | 127 |
| 8/25/2021 | | @ | Oak | W | Torres,G | 3 | 2 | | 78 | 50 | .609 | 4-6 | W1 | 128 |
| 8/26/2021 | | | Bos | W | Lamb | 10 | 5 | | 79 | 50 | .612 | 5-5 | W2 | 129 |
| 8/26/2021 | | @ | Oak | L | | 2 | 5 | | 79 | 51 | .608 | 4-6 | L1 | 130 |
| 8/27/2021 | | | Was | W | Correa | 5 | 3 | | 80 | 51 | .611 | 4-6 | W1 | 131 |
| 8/27/2021 | | @ | LAA | L | | 3 | 5 | | 80 | 52 | .606 | 4-6 | L1 | 132 |
| 8/28/2021 | | | Was | W | Torres,G | 8 | 6 | | 81 | 52 | .609 | 5-5 | W1 | 133 |
| 8/28/2021 | | @ | LAA | W | Torres,G | 11 | 2 | | 82 | 52 | .612 | 5-5 | W2 | 134 |
| 8/29/2021 | | | Was | W | Torres,G | 4 | 1 | | 83 | 52 | .615 | 6-4 | W3 | 135 |
| 8/29/2021 | | @ | LAA | W | Correa | 9 | 4 | | 84 | 52 | .618 | 7-3 | W4 | 136 |
| 8/30/2021 | | | Was | W | Miller,Bra | 10 | 6 | | 85 | 52 | .620 | 8-2 | W5 | 137 |
| 8/30/2021 | | @ | LAA | W | Lamb | 8 | 1 | | 86 | 52 | .623 | 8-2 | W6 | 138 |
| 9/7/2021 | | @ | ChW | L | | 4 | 5 | | 86 | 53 | .619 | 7-3 | L1 | 139 |
| 9/7/2021 | | | Det | W | Torres,G | 3 | 0 | | 87 | 53 | .621 | 8-2 | W1 | 140 |
| 9/8/2021 | | @ | ChW | W | Torres,G | 3 | 1 | | 88 | 53 | .624 | 8-2 | W2 | 141 |
| 9/8/2021 | | | Det | L | | 3 | 5 | | 88 | 54 | .620 | 8-2 | L1 | 142 |
| 9/9/2021 | | @ | ChW | L | | 0 | 14 | | 88 | 55 | .615 | 7-3 | L2 | 143 |
| 9/9/2021 | | | Det | W | Acuna Jr. | 3 | 0 | | 89 | 55 | .618 | 7-3 | W1 | 144 |
| 9/10/2021 | | @ | NYY | L | | 1 | 2 | | 89 | 56 | .614 | 6-4 | L1 | 145 |
| 9/10/2021 | | | Sea | W | Lamb | 13 | 2 | | 90 | 56 | .616 | 6-4 | W1 | 146 |
| 9/11/2021 | | @ | NYY | W | Torres,G | 9 | 4 | | 91 | 56 | .619 | 6-4 | W2 | 147 |
| 9/11/2021 | | | Sea | L | | 0 | 8 | | 91 | 57 | .615 | 5-5 | L1 | 148 |
| 9/12/2021 | | @ | NYY | L | | 3 | 8 | | 91 | 58 | .611 | 5-5 | L2 | 149 |
| 9/12/2021 | | | Sea | W | Anderson,Bri | 8 | 0 | | 92 | 58 | .613 | 5-5 | W1 | 150 |
| 9/13/2021 | | @ | NYY | W | Realmuto | 5 | 4 | | 93 | 58 | .616 | 5-5 | W2 | 151 |
| 9/13/2021 | | | Sea | W | Realmuto | 10 | 3 | | 94 | 58 | .618 | 6-4 | W3 | 152 |
| 9/24/2021 | | @ | Tor | W | | 6 | 5 | | 95 | 58 | .621 | 7-3 | W4 | 153 |
| 9/24/2021 | | | Min | L | | 5 | 6 | | 95 | 59 | .617 | 6-4 | L1 | 154 |
| 9/25/2021 | | @ | Tor | L | | 9 | 10 | | 95 | 60 | .613 | 6-4 | L2 | 155 |
| 9/25/2021 | | | Min | W | Acuna Jr. | 3 | 2 | | 96 | 60 | .615 | 6-4 | W1 | 156 |
| 9/26/2021 | | @ | Tor | L | | 6 | 7 | | 96 | 61 | .611 | 5-5 | L1 | 157 |
| 9/26/2021 | | | Min | W | Acuna Jr. | 5 | 4 | | 97 | 61 | .614 | 6-4 | W1 | 158 |
| 9/27/2021 | | | Min | L | | 4 | 6 | | 97 | 62 | .610 | 6-4 | L1 | 159 |
| 9/27/2021 | | @ | Min | W | Lamb | 9 | 6 | | 98 | 62 | .613 | 6-4 | W1 | 160 |
| 9/28/2021 | | | Min | L | | 3 | 5 | | 98 | 63 | .609 | 5-5 | L1 | 161 |
| 9/28/2021 | | @ | Min | W | Kepler | 9 | 6 | | 99 | 63 | .611 | 5-5 | W1 | 162 |