Team game results -- 2021 San Francisco Giants
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | Decision | Save | Versus | T |
| 3/29/2021 | | @ |  Mia | W | 10-4 | | Buehler | R | Buehler | | Alcantara,Sa | R |
| 3/29/2021 | | |  Cin | L | 6-7 | | Buehler | R | Buehler | | Banda | L |
| 3/30/2021 | | @ | Mia | W | 1-0 | | Wheeler | R | Wheeler | Hendriks | Arrieta | R |
| 3/30/2021 | | | Cin | W | 5-4 | | Wheeler | R | Chafin | Hendriks | Eovaldi | R |
| 3/31/2021 | | @ | Mia | W | 5-3 | | Kim | L | Kim | Chafin | Wright,K | R |
| 3/31/2021 | | | Cin | W | 7-6 | 10 | Kim | L | Hendriks | | Fedde | R |
| 4/1/2021 | | @ | Mia | W | 8-0 | | DeSclafani | R | DeSclafani | | Manning | R |
| 4/1/2021 | | | Cin | W | 5-4 | | DeSclafani | R | DeSclafani | Keller,K | Peralta,F | R |
| 4/2/2021 | | @ |  SDP | W | 5-3 | | Anderson,Ty | L | Petit | Hendriks | Sanchez,Aa | R |
| 4/2/2021 | | |  Ari | W | 5-4 | 10 | Anderson,Ty | L | Hendriks | | McHugh | R |
| 4/3/2021 | | @ | SDP | W | 8-4 | | Buehler | R | Buehler | | Nola,Aa | R |
| 4/3/2021 | | | Ari | W | 5-0 | | Buehler | R | Buehler | | Corbin | L |
| 4/4/2021 | | @ | SDP | W | 1-0 | | Wheeler | R | Wheeler | | Maeda | R |
| 4/4/2021 | | | Ari | W | 6-3 | | Wheeler | R | Karinchak | Hendriks | Strasburg | R |
| 4/6/2021 | | @ |  Col | L | 6-11 | | Kim | L | Kim | | Morton | R |
| 4/6/2021 | | |  LAD | W | 7-3 | | Kim | L | Kim | Hendriks | Allard | L |
| 4/7/2021 | | @ | Col | W | 9-2 | | DeSclafani | R | DeSclafani | | Montas | R |
| 4/7/2021 | | | LAD | W | 4-1 | | DeSclafani | R | DeSclafani | Chafin | Lucchesi | L |
| 4/8/2021 | | @ | Col | L | 5-6 | 10 | Anderson,Ty | L | Petit | | Ryu | L |
| 4/8/2021 | | | LAD | W | 2-1 | | Buehler | R | Familia | Hendriks | Musgrove | R |
| 4/19/2021 | | @ |  Atl | L | 2-8 | | Crowe | R | Crowe | | Soroka | R |
| 4/19/2021 | | |  StL | L | 2-10 | | Crowe | R | Crowe | | McCullers Jr. | R |
| 4/20/2021 | | @ | Atl | L | 4-5 | | Kay | L | Kay | | Marquez | R |
| 4/20/2021 | | | StL | W | 4-2 | | Kay | L | Petit | Hendriks | Mize | R |
| 4/21/2021 | | @ | Atl | L | 4-8 | | Garcia,Dei | R | Garcia,Dei | | Singer,B | R |
| 4/21/2021 | | | StL | L | 4-6 | | Garcia,Dei | R | Garcia,Dei | | Velasquez | R |
| 4/22/2021 | | @ | Atl | L | 2-5 | | Urquidy | R | Urquidy | | Young,Al | L |
| 4/22/2021 | | | StL | L | 2-5 | | Lopez,Re | R | Lopez,Re | | Snell | L |
| 4/23/2021 | | @ |  NYY | L | 1-3 | | Lopez,Re | R | Lopez,Re | | Bundy | R |
| 4/24/2021 | | @ | NYY | L | 1-7 | | Crowe | R | Crowe | | Minor | L |
| 4/25/2021 | | @ | NYY | L | 7-10 | | Kay | L | May,T | | Lamet | R |
| 4/27/2021 | | @ |  Mtl | L | 2-6 | | Garcia,Dei | R | Garcia,Dei | | Garcia,Ri | R |
| 4/28/2021 | | @ | Mtl | L | 1-3 | | Urquidy | R | Urquidy | | James,J | R |
| 4/29/2021 | | @ | Mtl | L | 1-5 | | Lopez,Re | R | Lopez,Re | | Anderson,Bre | L |
| 5/7/2021 | | |  Cle | W | 10-8 | | Crowe | R | Familia | Hendriks | Woodruff | R |
| 5/8/2021 | | | Cle | L | 3-9 | | Kay | L | Kay | | Verlander | R |
| 5/9/2021 | | | Cle | L | 2-3 | | Garcia,Dei | R | Tate | | Hendricks | R |
| 5/11/2021 | | |  Tor | W | 2-1 | | Lopez,Re | R | Lopez,Re | Hendriks | Yamaguchi | R |
| 5/12/2021 | | | Tor | W | 6-5 | | Urquidy | R | Familia | | Merryweather | R |
| 5/13/2021 | | | Tor | L | 5-7 | 10 | Crowe | R | Hendriks | | Smyly | L |
| 5/20/2021 | | @ |  Hou | W | 3-1 | | Buehler | R | Buehler | Hendriks | Glasnow | R |
| 5/20/2021 | | | Atl | L | 3-4 | | Buehler | R | Hendriks | | Young,Al | L |
| 5/21/2021 | | @ | Hou | L | 7-13 | | Wheeler | R | Wheeler | | Gonzalez,G | L |
| 5/21/2021 | | | Atl | L | 4-6 | | Wheeler | R | Wheeler | | Marquez | R |
| 5/22/2021 | | @ | Hou | W | 14-2 | | Lopez,Re | R | Lopez,Re | | Triggs | R |
| 5/22/2021 | | | Atl | L | 3-4 | | Lopez,Re | R | Hendriks | | Kershaw | L |
| 5/23/2021 | | @ | Hou | W | 5-2 | 10 | Anderson,Ty | L | Petit | Hendriks | Stroman | R |
| 5/23/2021 | | | Atl | W | 5-4 | | Anderson,Ty | L | May,T | | Singer,B | R |
| 5/24/2021 | | @ | LAD | W | 4-1 | | DeSclafani | R | DeSclafani | Hendriks | Sanchez,S | R |
| 5/24/2021 | | | Col | L | 1-2 | 10 | DeSclafani | R | Hendriks | | Ponce De Leon | R |
| 5/25/2021 | | @ | LAD | L | 3-4 | | Buehler | R | May,T | | Lucchesi | L |
| 5/25/2021 | | | Col | W | 5-1 | | Buehler | R | Buehler | | Morton | R |
| 5/26/2021 | | @ | LAD | W | 7-1 | | Wheeler | R | Wheeler | | Allard | L |
| 5/26/2021 | | | Col | L | 7-8 | 13 | Wheeler | R | Chafin | | Montas | R |
| 5/28/2021 | | @ |  ChC | L | 3-6 | | Lopez,Re | R | Lopez,Re | | Lindblom | R |
| 5/28/2021 | | |  Pit | L | 3-5 | | Lopez,Re | R | Lopez,Re | | Perez,Ma | L |
| 5/29/2021 | | @ | ChC | W | 2-0 | | Anderson,Ty | L | Anderson,Ty | Hendriks | Mikolas | R |
| 5/29/2021 | | | Pit | L | 0-6 | | Anderson,Ty | L | Anderson,Ty | | Senzatela | R |
| 5/30/2021 | | @ | ChC | W | 6-2 | | DeSclafani | R | DeSclafani | May,T | Smith,Ca | L |
| 5/30/2021 | | | Pit | W | 12-5 | | DeSclafani | R | DeSclafani | | Allen,L | L |
| 5/31/2021 | | @ | ChC | W | 5-2 | | Buehler | R | Buehler | | Boyd | L |
| 5/31/2021 | | | Pit | W | 4-3 | 10 | Buehler | R | Hendriks | | Plesac | R |
| 6/8/2021 | | @ |  Was | W | 10-5 | | Wheeler | R | Wheeler | | Pivetta | R |
| 6/9/2021 | | @ | Was | W | 4-1 | | Lopez,Re | R | Lopez,Re | Hendriks | Eflin | R |
| 6/10/2021 | | @ | Was | W | 8-6 | | Anderson,Ty | L | Karinchak | Hendriks | Duplantier | R |
| 6/11/2021 | | @ |  Bal | W | 6-4 | | Buehler | R | Buehler | Hendriks | Roark | R |
| 6/12/2021 | | @ | Bal | L | 4-5 | | DeSclafani | R | DeSclafani | | Yamamoto | R |
| 6/13/2021 | | @ | Bal | L | 2-4 | | Wheeler | R | Wheeler | | Foltynewicz | R |
| 6/15/2021 | | @ |  Bos | W | 10-8 | 12 | Lopez,Re | R | May,T | | Rodriguez,E | L |
| 6/16/2021 | | @ | Bos | W | 4-0 | | Anderson,Ty | L | Anderson,Ty | | Clarke | R |
| 6/17/2021 | | @ | Bos | W | 2-0 | | Buehler | R | Buehler | Chafin | Pena,Fe | R |
| 6/18/2021 | | |  ChW | W | 3-1 | | Wheeler | R | Karinchak | Hendriks | Ohtani | R |
| 6/19/2021 | | | ChW | L | 3-6 | | Lopez,Re | R | Lopez,Re | | Lester,Jon | L |
| 6/20/2021 | | | ChW | L | 2-5 | | Anderson,Ty | L | Anderson,Ty | | Giolito | R |
| 6/22/2021 | | |  Min | W | 8-2 | | Buehler | R | Buehler | | Ray,R | L |
| 6/23/2021 | | | Min | L | 6-8 | | DeSclafani | R | DeSclafani | | Patino | R |
| 6/24/2021 | | | Min | W | 4-3 | | Wheeler | R | Wheeler | Hendriks | Gallen | R |
| 6/25/2021 | | |  Det | W | 4-2 | | Lopez,Re | R | Familia | Hendriks | Happ,J.A. | L |
| 6/26/2021 | | | Det | W | 2-1 | | Anderson,Ty | L | Hendriks | | Salazar | R |
| 6/27/2021 | | | Det | W | 5-1 | | Buehler | R | Buehler | May,T | Rogers,Tr | L |
| 7/8/2021 | | @ |  Phi | L | 3-9 | | Wheeler | R | Wheeler | | Bieber | R |
| 7/8/2021 | | |  Mil | L | 0-1 | | Wheeler | R | Wheeler | | Kelly,M | R |
| 7/9/2021 | | @ | Phi | L | 2-7 | | DeSclafani | R | DeSclafani | | Castillo,L | R |
| 7/9/2021 | | | Mil | L | 2-3 | | DeSclafani | R | DeSclafani | | Suter | L |
| 7/10/2021 | | @ | Phi | L | 4-5 | | Anderson,Ty | L | Tate | | Carrasco | R |
| 7/10/2021 | | | Mil | L | 1-14 | | Anderson,Ty | L | Anderson,Ty | | Price | L |
| 7/11/2021 | | @ | Phi | W | 10-6 | 11 | Lopez,Re | R | May,T | | Jefferies | R |
| 7/11/2021 | | | Mil | L | 3-5 | | Lopez,Re | R | Lopez,Re | | Darvish | R |
| 7/12/2021 | | @ | Ari | W | 9-7 | | Buehler | R | Buehler | Tate | Gray,Jon | R |
| 7/12/2021 | | | SDP | W | 2-1 | | Buehler | R | Hendriks | | Nola,Aa | R |
| 7/13/2021 | | @ | Ari | W | 5-2 | | Wheeler | R | Wheeler | Keller,K | Corbin | L |
| 7/13/2021 | | | SDP | L | 0-2 | | Wheeler | R | Wheeler | | Scherzer | R |
| 7/14/2021 | | @ | Ari | W | 4-2 | | DeSclafani | R | DeSclafani | Petit | Strasburg | R |
| 7/14/2021 | | | SDP | W | 4-3 | 11 | DeSclafani | R | Familia | | Mengden | R |
| 7/16/2021 | | @ |  NYM | W | 3-1 | | Lopez,Re | R | Lopez,Re | Hendriks | Gausman | R |
| 7/16/2021 | | | Hou | L | 8-11 | | Lopez,Re | R | May,T | | Glasnow | R |
| 7/17/2021 | | @ | NYM | L | 1-3 | | Anderson,Ty | L | Anderson,Ty | | Gray,S | R |
| 7/17/2021 | | | Hou | W | 5-4 | 12 | Anderson,Ty | L | Petit | | Gonzalez,G | L |
| 7/18/2021 | | @ | NYM | L | 3-4 | | Wheeler | R | Wheeler | | Brault | L |
| 7/18/2021 | | | Hou | L | 1-3 | | Wheeler | R | Wheeler | | Howard,Sp | R |
| 7/19/2021 | | @ | NYM | W | 2-0 | | Buehler | R | Buehler | Hendriks | Tanaka | R |
| 7/19/2021 | | | Hou | L | 2-5 | | DeSclafani | R | DeSclafani | | Stroman | R |
| 7/27/2021 | | @ | Col | L | 2-8 | | DeSclafani | R | DeSclafani | | Greinke | R |
| 7/27/2021 | | | LAD | L | 2-5 | | DeSclafani | R | DeSclafani | | Musgrove | R |
| 7/28/2021 | | @ | Col | W | 6-4 | | Lopez,Re | R | Lopez,Re | Hendriks | Sadler | R |
| 7/28/2021 | | | LAD | L | 8-9 | 13 | Lopez,Re | R | Tate | | Berrios | R |
| 7/29/2021 | | @ | Col | W | 8-2 | | Wheeler | R | Wheeler | | Stripling | R |
| 7/29/2021 | | | LAD | W | 6-3 | | Wheeler | R | Wheeler | | Lucchesi | L |
| 7/30/2021 | | @ | SDP | W | 5-4 | | Buehler | R | Familia | Hendriks | Nola,Aa | R |
| 7/30/2021 | | | Ari | W | 5-1 | | Buehler | R | Buehler | | Gray,Jon | R |
| 7/31/2021 | | @ | SDP | W | 10-5 | | Anderson,Ty | L | Anderson,Ty | | Sanchez,Aa | R |
| 7/31/2021 | | | Ari | L | 0-2 | | Anderson,Ty | L | Anderson,Ty | | Lynn | R |
| 8/1/2021 | | @ | SDP | W | 8-4 | | DeSclafani | R | DeSclafani | Hendriks | Mengden | R |
| 8/1/2021 | | | Ari | L | 6-7 | 10 | DeSclafani | R | Familia | | Strasburg | R |
| 8/3/2021 | | @ | Cin | L | 0-2 | | Wheeler | R | Wheeler | | Bauer | R |
| 8/3/2021 | | | Phi | W | 3-2 | | Wheeler | R | Familia | | Castillo,L | R |
| 8/4/2021 | | @ | Cin | L | 4-10 | | Buehler | R | Buehler | | Hatch | R |
| 8/4/2021 | | | Phi | L | 3-5 | | Buehler | R | Buehler | | Clevinger | R |
| 8/5/2021 | | @ | Cin | W | 7-5 | | Anderson,Ty | L | Urquidy | Hendriks | Garrett,B | L |
| 8/5/2021 | | | Phi | L | 4-7 | | Anderson,Ty | L | Anderson,Ty | | Anderson,S | R |
| 8/6/2021 | | @ | Cin | W | 5-2 | | DeSclafani | R | DeSclafani | Hendriks | Borucki | L |
| 8/6/2021 | | | Phi | L | 2-6 | | DeSclafani | R | DeSclafani | | Mazza | R |
| 8/12/2021 | | @ | Mil | L | 3-8 | | Lopez,Re | R | Lopez,Re | | Darvish | R |
| 8/12/2021 | | | Mia | L | 3-4 | | Lopez,Re | R | Lopez,Re | | Shoemaker | R |
| 8/13/2021 | | @ | Mil | L | 1-9 | | Garcia,Dei | R | Garcia,Dei | | Kelly,M | R |
| 8/13/2021 | | | Mia | W | 7-4 | | Garcia,Dei | R | Tate | Hendriks | Gore,M | L |
| 8/14/2021 | | @ | Mil | L | 2-4 | | Urquidy | R | Urquidy | | Kluber | R |
| 8/14/2021 | | | Mia | W | 3-0 | | Urquidy | R | Urquidy | Barraclough | Menez | L |
| 8/15/2021 | | @ | Mil | W | 7-5 | | Crowe | R | Crowe | Chafin | Kopech | R |
| 8/15/2021 | | | Mia | L | 4-9 | | Crowe | R | Tate | | Alcantara,Sa | R |
| 8/16/2021 | | @ | StL | L | 2-3 | | Buehler | R | Buehler | | Skubal | L |
| 8/16/2021 | | | NYM | W | 4-2 | | Buehler | R | Buehler | Hendriks | Maeda | R |
| 8/17/2021 | | @ | StL | L | 2-3 | | Lopez,Re | R | Lopez,Re | | Heaney | L |
| 8/17/2021 | | | NYM | W | 8-6 | | Lopez,Re | R | Barraclough | Hendriks | Means | L |
| 8/18/2021 | | @ | StL | L | 0-13 | | Garcia,Dei | R | Garcia,Dei | | Velasquez | R |
| 8/18/2021 | | | NYM | W | 4-1 | | Garcia,Dei | R | Garcia,Dei | Barraclough | Tanaka | R |
| 8/19/2021 | | @ | StL | W | 5-4 | | Urquidy | R | Urquidy | Petit | Snell | L |
| 8/19/2021 | | | NYM | W | 8-7 | 14 | Urquidy | R | Hendriks | | Gausman | R |
| 8/31/2021 | | @ | LAD | L | 5-6 | | Kim | L | Roe | | Zimmermann,B | L |
| 8/31/2021 | | | Col | W | 3-2 | | Wheeler | R | Rainey | Familia | Heller | R |
| 9/1/2021 | | @ | LAD | W | 4-3 | 11 | DeSclafani | R | Familia | Barraclough | Musgrove | R |
| 9/1/2021 | | | Col | W | 11-0 | | DeSclafani | R | DeSclafani | | Rusin | L |
| 9/2/2021 | | @ | LAD | W | 3-0 | | Wheeler | R | Wheeler | Petit | Berrios | R |
| 9/2/2021 | | | Col | W | 2-0 | | Buehler | R | Buehler | | Stripling | R |
| 9/3/2021 | | @ | Pit | W | 14-5 | | Buehler | R | Buehler | | Garcia,Ri | R |
| 9/3/2021 | | | ChC | W | 2-1 | | Urquidy | R | Rainey | | Smith,Ca | L |
| 9/4/2021 | | @ | Pit | W | 3-2 | | Urquidy | R | Urquidy | Petit | Plesac | R |
| 9/4/2021 | | | ChC | W | 9-1 | | Garcia,Dei | R | Garcia,Dei | | Lindblom | R |
| 9/5/2021 | | @ | Pit | W | 8-7 | | Kim | L | Kim | Barraclough | Neidert | R |
| 9/5/2021 | | | ChC | W | 2-1 | | Wheeler | R | Wheeler | Familia | Norris,D | L |
| 9/6/2021 | | @ | Pit | L | 3-13 | | Garcia,Dei | R | Garcia,Dei | | Morejon | L |
| 9/6/2021 | | | ChC | L | 3-13 | | DeSclafani | R | DeSclafani | | Pearson | R |
| 9/17/2021 | | @ | Ari | L | 3-7 | | Wheeler | R | Wheeler | | Gray,Jon | R |
| 9/17/2021 | | | SDP | L | 0-3 | | Urquidy | R | Urquidy | | Scherzer | R |
| 9/18/2021 | | @ | Ari | W | 8-4 | | Buehler | R | Buehler | Familia | McHugh | R |
| 9/18/2021 | | | SDP | L | 3-4 | | Wheeler | R | Wheeler | | Nola,Aa | R |
| 9/19/2021 | | @ | Ari | L | 2-8 | | Urquidy | R | Urquidy | | Strasburg | R |
| 9/19/2021 | | | SDP | W | 4-2 | | Buehler | R | Buehler | Familia | Bundy | R |
| 9/20/2021 | | @ | SDP | W | 2-1 | | DeSclafani | R | DeSclafani | Hendriks | Kittredge | R |
| 9/20/2021 | | | Col | W | 3-2 | 14 | DeSclafani | R | Barraclough | | Hardy | L |
| 9/21/2021 | | @ | SDP | W | 11-7 | | Lopez,Re | R | May,T | | Nola,Aa | R |
| 9/21/2021 | | | Col | L | 5-6 | 11 | Lopez,Re | R | May,T | | Rusin | L |
| Other |
| Game information | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | | W | L | Pct | L10 | Strk | Gm# |
| 3/29/2021 | | @ | Mia | W | Merrifield | 10 | 4 | | 1 | 0 | 1.000 | 1-0 | W1 | 1 |
| 3/29/2021 | | | Cin | L | | 6 | 7 | | 1 | 1 | .500 | 1-1 | L1 | 2 |
| 3/30/2021 | | @ | Mia | W | Alonso,P | 1 | 0 | | 2 | 1 | .667 | 2-1 | W1 | 3 |
| 3/30/2021 | | | Cin | W | Goodrum | 5 | 4 | | 3 | 1 | .750 | 3-1 | W2 | 4 |
| 3/31/2021 | | @ | Mia | W | | 5 | 3 | | 4 | 1 | .800 | 4-1 | W3 | 5 |
| 3/31/2021 | | | Cin | W | Goodrum | 7 | 6 | | 5 | 1 | .833 | 5-1 | W4 | 6 |
| 4/1/2021 | | @ | Mia | W | Alonso,P | 8 | 0 | | 6 | 1 | .857 | 6-1 | W5 | 7 |
| 4/1/2021 | | | Cin | W | Hiura | 5 | 4 | | 7 | 1 | .875 | 7-1 | W6 | 8 |
| 4/2/2021 | | @ | SDP | W | Alonso,P | 5 | 3 | | 8 | 1 | .889 | 8-1 | W7 | 9 |
| 4/2/2021 | | | Ari | W | Goodrum | 5 | 4 | | 9 | 1 | .900 | 9-1 | W8 | 10 |
| 4/3/2021 | | @ | SDP | W | Sierra,M | 8 | 4 | | 10 | 1 | .909 | 9-1 | W9 | 11 |
| 4/3/2021 | | | Ari | W | Grichuk | 5 | 0 | | 11 | 1 | .917 | 10-0 | W10 | 12 |
| 4/4/2021 | | @ | SDP | W | McNeil | 1 | 0 | | 12 | 1 | .923 | 10-0 | W11 | 13 |
| 4/4/2021 | | | Ari | W | Hiura | 6 | 3 | | 13 | 1 | .929 | 10-0 | W12 | 14 |
| 4/6/2021 | | @ | Col | L | | 6 | 11 | | 13 | 2 | .867 | 9-1 | L1 | 15 |
| 4/6/2021 | | | LAD | W | Perez,Mi | 7 | 3 | | 14 | 2 | .875 | 9-1 | W1 | 16 |
| 4/7/2021 | | @ | Col | W | Alonso,P | 9 | 2 | | 15 | 2 | .882 | 9-1 | W2 | 17 |
| 4/7/2021 | | | LAD | W | Hiura | 4 | 1 | | 16 | 2 | .889 | 9-1 | W3 | 18 |
| 4/8/2021 | | @ | Col | L | | 5 | 6 | | 16 | 3 | .842 | 8-2 | L1 | 19 |
| 4/8/2021 | | | LAD | W | Viloria | 2 | 1 | | 17 | 3 | .850 | 8-2 | W1 | 20 |
| 4/19/2021 | | @ | Atl | L | | 2 | 8 | | 17 | 4 | .810 | 7-3 | L1 | 21 |
| 4/19/2021 | | | StL | L | | 2 | 10 | | 17 | 5 | .773 | 6-4 | L2 | 22 |
| 4/20/2021 | | @ | Atl | L | | 4 | 5 | | 17 | 6 | .739 | 5-5 | L3 | 23 |
| 4/20/2021 | | | StL | W | McNeil | 4 | 2 | | 18 | 6 | .750 | 5-5 | W1 | 24 |
| 4/21/2021 | | @ | Atl | L | | 4 | 8 | | 18 | 7 | .720 | 5-5 | L1 | 25 |
| 4/21/2021 | | | StL | L | | 4 | 6 | | 18 | 8 | .692 | 4-6 | L2 | 26 |
| 4/22/2021 | | @ | Atl | L | | 2 | 5 | | 18 | 9 | .667 | 3-7 | L3 | 27 |
| 4/22/2021 | | | StL | L | | 2 | 5 | | 18 | 10 | .643 | 2-8 | L4 | 28 |
| 4/23/2021 | | @ | NYY | L | | 1 | 3 | | 18 | 11 | .621 | 2-8 | L5 | 29 |
| 4/24/2021 | | @ | NYY | L | | 1 | 7 | | 18 | 12 | .600 | 1-9 | L6 | 30 |
| 4/25/2021 | | @ | NYY | L | | 7 | 10 | | 18 | 13 | .581 | 1-9 | L7 | 31 |
| 4/27/2021 | | @ | Mtl | L | | 2 | 6 | | 18 | 14 | .563 | 1-9 | L8 | 32 |
| 4/28/2021 | | @ | Mtl | L | | 1 | 3 | | 18 | 15 | .545 | 1-9 | L9 | 33 |
| 4/29/2021 | | @ | Mtl | L | | 1 | 5 | | 18 | 16 | .529 | 0-10 | L10 | 34 |
| 5/7/2021 | | | Cle | W | Martin Jr. | 10 | 8 | | 19 | 16 | .543 | 1-9 | W1 | 35 |
| 5/8/2021 | | | Cle | L | | 3 | 9 | | 19 | 17 | .528 | 1-9 | L1 | 36 |
| 5/9/2021 | | | Cle | L | | 2 | 3 | | 19 | 18 | .514 | 1-9 | L2 | 37 |
| 5/11/2021 | | | Tor | W | McNeil | 2 | 1 | | 20 | 18 | .526 | 2-8 | W1 | 38 |
| 5/12/2021 | | | Tor | W | Miller,I | 6 | 5 | | 21 | 18 | .538 | 3-7 | W2 | 39 |
| 5/13/2021 | | | Tor | L | | 5 | 7 | | 21 | 19 | .525 | 3-7 | L1 | 40 |
| 5/20/2021 | | @ | Hou | W | | 3 | 1 | | 22 | 19 | .537 | 4-6 | W1 | 41 |
| 5/20/2021 | | | Atl | L | | 3 | 4 | | 22 | 20 | .524 | 4-6 | L1 | 42 |
| 5/21/2021 | | @ | Hou | L | | 7 | 13 | | 22 | 21 | .512 | 4-6 | L2 | 43 |
| 5/21/2021 | | | Atl | L | | 4 | 6 | | 22 | 22 | .500 | 4-6 | L3 | 44 |
| 5/22/2021 | | @ | Hou | W | Viloria | 14 | 2 | | 23 | 22 | .511 | 4-6 | W1 | 45 |
| 5/22/2021 | | | Atl | L | | 3 | 4 | | 23 | 23 | .500 | 4-6 | L1 | 46 |
| 5/23/2021 | | @ | Hou | W | Hiura | 5 | 2 | | 24 | 23 | .511 | 5-5 | W1 | 47 |
| 5/23/2021 | | | Atl | W | Gordon,N | 5 | 4 | | 25 | 23 | .521 | 5-5 | W2 | 48 |
| 5/24/2021 | | @ | LAD | W | | 4 | 1 | | 26 | 23 | .531 | 5-5 | W3 | 49 |
| 5/24/2021 | | | Col | L | | 1 | 2 | | 26 | 24 | .520 | 5-5 | L1 | 50 |
| 5/25/2021 | | @ | LAD | L | | 3 | 4 | | 26 | 25 | .510 | 4-6 | L2 | 51 |
| 5/25/2021 | | | Col | W | Hiura | 5 | 1 | | 27 | 25 | .519 | 5-5 | W1 | 52 |
| 5/26/2021 | | @ | LAD | W | Hiura | 7 | 1 | | 28 | 25 | .528 | 6-4 | W2 | 53 |
| 5/26/2021 | | | Col | L | | 7 | 8 | | 28 | 26 | .519 | 6-4 | L1 | 54 |
| 5/28/2021 | | @ | ChC | L | | 3 | 6 | | 28 | 27 | .509 | 5-5 | L2 | 55 |
| 5/28/2021 | | | Pit | L | | 3 | 5 | | 28 | 28 | .500 | 5-5 | L3 | 56 |
| 5/29/2021 | | @ | ChC | W | | 2 | 0 | | 29 | 28 | .509 | 5-5 | W1 | 57 |
| 5/29/2021 | | | Pit | L | | 0 | 6 | | 29 | 29 | .500 | 4-6 | L1 | 58 |
| 5/30/2021 | | @ | ChC | W | Goodrum | 6 | 2 | | 30 | 29 | .508 | 4-6 | W1 | 59 |
| 5/30/2021 | | | Pit | W | McNeil | 12 | 5 | | 31 | 29 | .517 | 5-5 | W2 | 60 |
| 5/31/2021 | | @ | ChC | W | | 5 | 2 | | 32 | 29 | .525 | 6-4 | W3 | 61 |
| 5/31/2021 | | | Pit | W | Merrifield | 4 | 3 | | 33 | 29 | .532 | 6-4 | W4 | 62 |
| 6/8/2021 | | @ | Was | W | Merrifield | 10 | 5 | | 34 | 29 | .540 | 6-4 | W5 | 63 |
| 6/9/2021 | | @ | Was | W | Hiura | 4 | 1 | | 35 | 29 | .547 | 7-3 | W6 | 64 |
| 6/10/2021 | | @ | Was | W | Alonso,P | 8 | 6 | | 36 | 29 | .554 | 8-2 | W7 | 65 |
| 6/11/2021 | | @ | Bal | W | Alonso,P | 6 | 4 | | 37 | 29 | .561 | 9-1 | W8 | 66 |
| 6/12/2021 | | @ | Bal | L | | 4 | 5 | | 37 | 30 | .552 | 8-2 | L1 | 67 |
| 6/13/2021 | | @ | Bal | L | | 2 | 4 | | 37 | 31 | .544 | 8-2 | L2 | 68 |
| 6/15/2021 | | @ | Bos | W | McNeil | 10 | 8 | | 38 | 31 | .551 | 8-2 | W1 | 69 |
| 6/16/2021 | | @ | Bos | W | Alonso,P | 4 | 0 | | 39 | 31 | .557 | 8-2 | W2 | 70 |
| 6/17/2021 | | @ | Bos | W | Sierra,M | 2 | 0 | | 40 | 31 | .563 | 8-2 | W3 | 71 |
| 6/18/2021 | | | ChW | W | Merrifield | 3 | 1 | | 41 | 31 | .569 | 8-2 | W4 | 72 |
| 6/19/2021 | | | ChW | L | | 3 | 6 | | 41 | 32 | .562 | 7-3 | L1 | 73 |
| 6/20/2021 | | | ChW | L | | 2 | 5 | | 41 | 33 | .554 | 6-4 | L2 | 74 |
| 6/22/2021 | | | Min | W | Hiura | 8 | 2 | | 42 | 33 | .560 | 6-4 | W1 | 75 |
| 6/23/2021 | | | Min | L | | 6 | 8 | | 42 | 34 | .553 | 5-5 | L1 | 76 |
| 6/24/2021 | | | Min | W | McNeil | 4 | 3 | | 43 | 34 | .558 | 6-4 | W1 | 77 |
| 6/25/2021 | | | Det | W | Miller,I | 4 | 2 | | 44 | 34 | .564 | 7-3 | W2 | 78 |
| 6/26/2021 | | | Det | W | Merrifield | 2 | 1 | | 45 | 34 | .570 | 7-3 | W3 | 79 |
| 6/27/2021 | | | Det | W | Gordon,N | 5 | 1 | | 46 | 34 | .575 | 7-3 | W4 | 80 |
| 7/8/2021 | | @ | Phi | L | | 3 | 9 | | 46 | 35 | .568 | 6-4 | L1 | 81 |
| 7/8/2021 | | | Mil | L | | 0 | 1 | | 46 | 36 | .561 | 5-5 | L2 | 82 |
| 7/9/2021 | | @ | Phi | L | | 2 | 7 | | 46 | 37 | .554 | 5-5 | L3 | 83 |
| 7/9/2021 | | | Mil | L | | 2 | 3 | | 46 | 38 | .548 | 5-5 | L4 | 84 |
| 7/10/2021 | | @ | Phi | L | | 4 | 5 | | 46 | 39 | .541 | 4-6 | L5 | 85 |
| 7/10/2021 | | | Mil | L | | 1 | 14 | | 46 | 40 | .535 | 4-6 | L6 | 86 |
| 7/11/2021 | | @ | Phi | W | | 10 | 6 | | 47 | 40 | .540 | 4-6 | W1 | 87 |
| 7/11/2021 | | | Mil | L | | 3 | 5 | | 47 | 41 | .534 | 3-7 | L1 | 88 |
| 7/12/2021 | | @ | Ari | W | Alonso,P | 9 | 7 | | 48 | 41 | .539 | 3-7 | W1 | 89 |
| 7/12/2021 | | | SDP | W | Miller,I | 2 | 1 | | 49 | 41 | .544 | 3-7 | W2 | 90 |
| 7/13/2021 | | @ | Ari | W | Merrifield | 5 | 2 | | 50 | 41 | .549 | 4-6 | W3 | 91 |
| 7/13/2021 | | | SDP | L | | 0 | 2 | | 50 | 42 | .543 | 4-6 | L1 | 92 |
| 7/14/2021 | | @ | Ari | W | McNeil | 4 | 2 | | 51 | 42 | .548 | 5-5 | W1 | 93 |
| 7/14/2021 | | | SDP | W | McNeil | 4 | 3 | | 52 | 42 | .553 | 6-4 | W2 | 94 |
| 7/16/2021 | | @ | NYM | W | Merrifield | 3 | 1 | | 53 | 42 | .558 | 7-3 | W3 | 95 |
| 7/16/2021 | | | Hou | L | | 8 | 11 | | 53 | 43 | .552 | 7-3 | L1 | 96 |
| 7/17/2021 | | @ | NYM | L | | 1 | 3 | | 53 | 44 | .546 | 6-4 | L2 | 97 |
| 7/17/2021 | | | Hou | W | Alonso,P | 5 | 4 | | 54 | 44 | .551 | 7-3 | W1 | 98 |
| 7/18/2021 | | @ | NYM | L | | 3 | 4 | | 54 | 45 | .545 | 6-4 | L1 | 99 |
| 7/18/2021 | | | Hou | L | | 1 | 3 | | 54 | 46 | .540 | 5-5 | L2 | 100 |
| 7/19/2021 | | @ | NYM | W | McNeil | 2 | 0 | | 55 | 46 | .545 | 5-5 | W1 | 101 |
| 7/19/2021 | | | Hou | L | | 2 | 5 | | 55 | 47 | .539 | 5-5 | L1 | 102 |
| 7/27/2021 | | @ | Col | L | | 2 | 8 | | 55 | 48 | .534 | 4-6 | L2 | 103 |
| 7/27/2021 | | | LAD | L | | 2 | 5 | | 55 | 49 | .529 | 3-7 | L3 | 104 |
| 7/28/2021 | | @ | Col | W | Alonso,P | 6 | 4 | | 56 | 49 | .533 | 3-7 | W1 | 105 |
| 7/28/2021 | | | LAD | L | | 8 | 9 | | 56 | 50 | .528 | 3-7 | L1 | 106 |
| 7/29/2021 | | @ | Col | W | Sierra,M | 8 | 2 | | 57 | 50 | .533 | 4-6 | W1 | 107 |
| 7/29/2021 | | | LAD | W | | 6 | 3 | | 58 | 50 | .537 | 4-6 | W2 | 108 |
| 7/30/2021 | | @ | SDP | W | | 5 | 4 | | 59 | 50 | .541 | 5-5 | W3 | 109 |
| 7/30/2021 | | | Ari | W | Hiura | 5 | 1 | | 60 | 50 | .545 | 6-4 | W4 | 110 |
| 7/31/2021 | | @ | SDP | W | McNeil | 10 | 5 | | 61 | 50 | .550 | 6-4 | W5 | 111 |
| 7/31/2021 | | | Ari | L | | 0 | 2 | | 61 | 51 | .545 | 6-4 | L1 | 112 |
| 8/1/2021 | | @ | SDP | W | Miller,I | 8 | 4 | | 62 | 51 | .549 | 7-3 | W1 | 113 |
| 8/1/2021 | | | Ari | L | | 6 | 7 | | 62 | 52 | .544 | 7-3 | L1 | 114 |
| 8/3/2021 | | @ | Cin | L | | 0 | 2 | | 62 | 53 | .539 | 6-4 | L2 | 115 |
| 8/3/2021 | | | Phi | W | Gordon,N | 3 | 2 | | 63 | 53 | .543 | 7-3 | W1 | 116 |
| 8/4/2021 | | @ | Cin | L | | 4 | 10 | | 63 | 54 | .538 | 6-4 | L1 | 117 |
| 8/4/2021 | | | Phi | L | | 3 | 5 | | 63 | 55 | .534 | 5-5 | L2 | 118 |
| 8/5/2021 | | @ | Cin | W | Hiura | 7 | 5 | | 64 | 55 | .538 | 5-5 | W1 | 119 |
| 8/5/2021 | | | Phi | L | | 4 | 7 | | 64 | 56 | .533 | 4-6 | L1 | 120 |
| 8/6/2021 | | @ | Cin | W | Grichuk | 5 | 2 | | 65 | 56 | .537 | 4-6 | W1 | 121 |
| 8/6/2021 | | | Phi | L | | 2 | 6 | | 65 | 57 | .533 | 4-6 | L1 | 122 |
| 8/12/2021 | | @ | Mil | L | | 3 | 8 | | 65 | 58 | .528 | 3-7 | L2 | 123 |
| 8/12/2021 | | | Mia | L | | 3 | 4 | | 65 | 59 | .524 | 3-7 | L3 | 124 |
| 8/13/2021 | | @ | Mil | L | | 1 | 9 | | 65 | 60 | .520 | 3-7 | L4 | 125 |
| 8/13/2021 | | | Mia | W | Mejia,E | 7 | 4 | | 66 | 60 | .524 | 3-7 | W1 | 126 |
| 8/14/2021 | | @ | Mil | L | | 2 | 4 | | 66 | 61 | .520 | 3-7 | L1 | 127 |
| 8/14/2021 | | | Mia | W | Ward,T | 3 | 0 | | 67 | 61 | .523 | 4-6 | W1 | 128 |
| 8/15/2021 | | @ | Mil | W | Martin Jr. | 7 | 5 | | 68 | 61 | .527 | 4-6 | W2 | 129 |
| 8/15/2021 | | | Mia | L | | 4 | 9 | | 68 | 62 | .523 | 4-6 | L1 | 130 |
| 8/16/2021 | | @ | StL | L | | 2 | 3 | | 68 | 63 | .519 | 3-7 | L2 | 131 |
| 8/16/2021 | | | NYM | W | Hiura | 4 | 2 | | 69 | 63 | .523 | 4-6 | W1 | 132 |
| 8/17/2021 | | @ | StL | L | | 2 | 3 | | 69 | 64 | .519 | 4-6 | L1 | 133 |
| 8/17/2021 | | | NYM | W | | 8 | 6 | | 70 | 64 | .522 | 5-5 | W1 | 134 |
| 8/18/2021 | | @ | StL | L | | 0 | 13 | | 70 | 65 | .519 | 5-5 | L1 | 135 |
| 8/18/2021 | | | NYM | W | Sierra,M | 4 | 1 | | 71 | 65 | .522 | 5-5 | W1 | 136 |
| 8/19/2021 | | @ | StL | W | Sierra,M | 5 | 4 | | 72 | 65 | .526 | 6-4 | W2 | 137 |
| 8/19/2021 | | | NYM | W | Merrifield | 8 | 7 | | 73 | 65 | .529 | 6-4 | W3 | 138 |
| 8/31/2021 | | @ | LAD | L | | 5 | 6 | | 73 | 66 | .525 | 5-5 | L1 | 139 |
| 8/31/2021 | | | Col | W | Hiura | 3 | 2 | | 74 | 66 | .529 | 6-4 | W1 | 140 |
| 9/1/2021 | | @ | LAD | W | Alonso,P | 4 | 3 | | 75 | 66 | .532 | 7-3 | W2 | 141 |
| 9/1/2021 | | | Col | W | Grichuk | 11 | 0 | | 76 | 66 | .535 | 7-3 | W3 | 142 |
| 9/2/2021 | | @ | LAD | W | Gordon,N | 3 | 0 | | 77 | 66 | .538 | 8-2 | W4 | 143 |
| 9/2/2021 | | | Col | W | Sierra,M | 2 | 0 | | 78 | 66 | .542 | 8-2 | W5 | 144 |
| 9/3/2021 | | @ | Pit | W | Sierra,M | 14 | 5 | | 79 | 66 | .545 | 9-1 | W6 | 145 |
| 9/3/2021 | | | ChC | W | Perez,Mi | 2 | 1 | | 80 | 66 | .548 | 9-1 | W7 | 146 |
| 9/4/2021 | | @ | Pit | W | Gordon,N | 3 | 2 | | 81 | 66 | .551 | 9-1 | W8 | 147 |
| 9/4/2021 | | | ChC | W | Alonso,P | 9 | 1 | | 82 | 66 | .554 | 9-1 | W9 | 148 |
| 9/5/2021 | | @ | Pit | W | Ward,T | 8 | 7 | | 83 | 66 | .557 | 10-0 | W10 | 149 |
| 9/5/2021 | | | ChC | W | Ward,T | 2 | 1 | | 84 | 66 | .560 | 10-0 | W11 | 150 |
| 9/6/2021 | | @ | Pit | L | | 3 | 13 | | 84 | 67 | .556 | 9-1 | L1 | 151 |
| 9/6/2021 | | | ChC | L | | 3 | 13 | | 84 | 68 | .553 | 8-2 | L2 | 152 |
| 9/17/2021 | | @ | Ari | L | | 3 | 7 | | 84 | 69 | .549 | 7-3 | L3 | 153 |
| 9/17/2021 | | | SDP | L | | 0 | 3 | | 84 | 70 | .545 | 6-4 | L4 | 154 |
| 9/18/2021 | | @ | Ari | W | Alonso,P | 8 | 4 | | 85 | 70 | .548 | 6-4 | W1 | 155 |
| 9/18/2021 | | | SDP | L | | 3 | 4 | | 85 | 71 | .545 | 5-5 | L1 | 156 |
| 9/19/2021 | | @ | Ari | L | | 2 | 8 | | 85 | 72 | .541 | 4-6 | L2 | 157 |
| 9/19/2021 | | | SDP | W | Merrifield | 4 | 2 | | 86 | 72 | .544 | 4-6 | W1 | 158 |
| 9/20/2021 | | @ | SDP | W | | 2 | 1 | | 87 | 72 | .547 | 4-6 | W2 | 159 |
| 9/20/2021 | | | Col | W | | 3 | 2 | | 88 | 72 | .550 | 4-6 | W3 | 160 |
| 9/21/2021 | | @ | SDP | W | Gerber,M | 11 | 7 | | 89 | 72 | .553 | 5-5 | W4 | 161 |
| 9/21/2021 | | | Col | L | | 5 | 6 | | 89 | 73 | .549 | 5-5 | L1 | 162 |