Team game results -- 2021 San Diego Padres
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | Decision | Save | Versus | T |
| 3/29/2021 | | @ |  Atl | W | 3-1 | 13 | Scherzer | R | Pagan | Givens | Kershaw | L |
| 3/29/2021 | | |  ChC | W | 3-0 | | Nola,Aa | R | Nola,Aa | Pagan | Boyd | L |
| 3/30/2021 | | @ | Atl | L | 0-7 | | Nola,Aa | R | Nola,Aa | | Marquez | R |
| 3/30/2021 | | | ChC | L | 4-6 | | Maeda | R | Maeda | | Mikolas | R |
| 3/31/2021 | | @ | Atl | W | 4-2 | | Maeda | R | Maeda | Pagan | Young,Al | L |
| 3/31/2021 | | | ChC | W | 4-2 | 12 | Scherzer | R | Workman | | Norris,D | L |
| 4/1/2021 | | @ | Atl | W | 4-3 | | Sanchez,Aa | R | Sanchez,Aa | Workman | Santana,Er | R |
| 4/1/2021 | | | ChC | W | 9-8 | 10 | Peacock,B | R | Bracho | | Pearson | R |
| 4/2/2021 | | @ |  LAD | L | 2-3 | | Mengden | R | Black | | Sanchez,S | R |
| 4/2/2021 | | |  SFG | L | 3-5 | | Sanchez,Aa | R | Pagan | | Anderson,Ty | L |
| 4/3/2021 | | @ | LAD | L | 1-3 | | Nola,Aa | R | Bracho | | Berrios | R |
| 4/3/2021 | | | SFG | L | 4-8 | | Nola,Aa | R | Nola,Aa | | Buehler | R |
| 4/4/2021 | | @ | LAD | W | 14-9 | | Peacock,B | R | Pagan | | Musgrove | R |
| 4/4/2021 | | | SFG | L | 0-1 | | Maeda | R | Maeda | | Wheeler | R |
| 4/6/2021 | | @ |  Ari | L | 6-12 | | Scherzer | R | Scherzer | | Lynn | R |
| 4/6/2021 | | |  Col | L | 3-4 | 13 | Scherzer | R | Workman | | Morton | R |
| 4/7/2021 | | @ | Ari | W | 6-5 | | Maeda | R | Givens | Wingenter | Gray,Jon | R |
| 4/7/2021 | | | Col | L | 7-9 | | Peacock,B | R | Bracho | | Montas | R |
| 4/8/2021 | | @ | Ari | L | 2-4 | | Nola,Aa | R | Nola,Aa | | Corbin | L |
| 4/8/2021 | | | Col | L | 0-1 | | Nola,Aa | R | Nola,Aa | | Ryu | L |
| 4/19/2021 | | @ |  Pit | W | 4-3 | 10 | Peacock,B | R | Ramos,E | Workman | Senzatela | R |
| 4/19/2021 | | |  Mil | L | 4-5 | | Nola,Aa | R | Nola,Aa | | Kopech | R |
| 4/20/2021 | | @ | Pit | W | 13-3 | 10 | Sanchez,Aa | R | Black | | Plesac | R |
| 4/20/2021 | | | Mil | L | 3-4 | | Scherzer | R | Scherzer | | Kelly,M | R |
| 4/21/2021 | | @ | Pit | W | 9-2 | | Maeda | R | Maeda | | Bolanos | R |
| 4/21/2021 | | | Mil | L | 3-6 | | Sanchez,Aa | R | Sanchez,Aa | | Price | L |
| 4/22/2021 | | @ | Pit | L | 1-2 | 12 | Nola,Aa | R | Givens | | Perez,Ma | L |
| 4/22/2021 | | | Mil | L | 4-5 | 10 | Maeda | R | Pagan | | Civale | R |
| 4/23/2021 | | @ |  Was | W | 10-3 | | Scherzer | R | Scherzer | | Barria | R |
| 4/24/2021 | | @ | Was | L | 1-2 | | Peacock,B | R | Peacock,B | | McKay,B | L |
| 4/25/2021 | | @ | Was | L | 1-2 | 10 | Sanchez,Aa | R | Givens | | Pivetta | R |
| 4/27/2021 | | @ |  NYY | W | 8-2 | | Nola,Aa | R | Nola,Aa | | Flaherty,J | R |
| 4/28/2021 | | @ | NYY | W | 7-6 | | Maeda | R | Maeda | Workman | Javier | R |
| 4/29/2021 | | @ | NYY | L | 4-6 | | Scherzer | R | Scherzer | | Bundy | R |
| 5/7/2021 | | |  Det | W | 10-4 | | Nola,Aa | R | Nola,Aa | | Duffy,D | L |
| 5/8/2021 | | | Det | W | 4-0 | | Scherzer | R | Scherzer | | Fulmer,M | R |
| 5/9/2021 | | | Det | L | 1-2 | | Sanchez,Aa | R | Givens | | Sheffield,Ju | L |
| 5/11/2021 | | |  ChW | L | 5-6 | | Maeda | R | Black | | Porcello | R |
| 5/12/2021 | | | ChW | W | 4-3 | | Peacock,B | R | Workman | | Bassitt | R |
| 5/13/2021 | | | ChW | L | 3-9 | | Nola,Aa | R | Nola,Aa | | Lester,Jon | L |
| 5/20/2021 | | @ |  Cin | L | 3-5 | | Peacock,B | R | Peacock,B | | Borucki | L |
| 5/20/2021 | | | Pit | W | 16-3 | | Scherzer | R | Scherzer | | Plesac | R |
| 5/21/2021 | | @ | Cin | W | 8-5 | 10 | Sanchez,Aa | R | Workman | | Peralta,F | R |
| 5/21/2021 | | | Pit | L | 8-10 | | Peacock,B | R | Peacock,B | | Bolanos | R |
| 5/22/2021 | | @ | Cin | L | 6-12 | | Nola,Aa | R | Nola,Aa | | Bauer | R |
| 5/22/2021 | | | Pit | W | 2-1 | | Maeda | R | Maeda | Workman | Perez,Ma | L |
| 5/23/2021 | | @ | Cin | W | 15-10 | | Maeda | R | Maeda | Pagan | Hatch | R |
| 5/23/2021 | | | Pit | W | 5-3 | | Sanchez,Aa | R | Workman | Pagan | Senzatela | R |
| 5/24/2021 | | @ | Col | W | 12-3 | | Scherzer | R | Scherzer | | Ponce De Leon | R |
| 5/24/2021 | | | Ari | W | 1-0 | | Nola,Aa | R | Nola,Aa | Workman | McHugh | R |
| 5/25/2021 | | @ | Col | L | 4-9 | | Peacock,B | R | Peacock,B | | Morton | R |
| 5/25/2021 | | | Ari | W | 6-1 | | Scherzer | R | Scherzer | | Corbin | L |
| 5/26/2021 | | @ | Col | W | 9-4 | | Nola,Aa | R | Nola,Aa | | Montas | R |
| 5/26/2021 | | | Ari | L | 9-16 | | Peacock,B | R | Peacock,B | | Newcomb | L |
| 5/28/2021 | | @ |  StL | W | 7-6 | 10 | Maeda | R | Workman | | Snell | L |
| 5/28/2021 | | |  Phi | W | 6-2 | | Maeda | R | Maeda | | Castillo,L | R |
| 5/29/2021 | | @ | StL | L | 2-7 | | Scherzer | R | Scherzer | | McCullers Jr. | R |
| 5/29/2021 | | | Phi | L | 2-6 | | Sanchez,Aa | R | Sanchez,Aa | | Carrasco | R |
| 5/30/2021 | | @ | StL | W | 11-3 | | Sanchez,Aa | R | Sanchez,Aa | | Velasquez | R |
| 5/30/2021 | | | Phi | W | 5-3 | | Nola,Aa | R | Nola,Aa | Workman | Chirinos,Y | R |
| 5/31/2021 | | @ | StL | W | 9-4 | | Nola,Aa | R | Nola,Aa | | Peterson,Da | L |
| 5/31/2021 | | | Phi | L | 7-8 | | Scherzer | R | Workman | | Sims,L | R |
| 6/8/2021 | | @ |  Bal | W | 7-1 | | Maeda | R | Maeda | | Foltynewicz | R |
| 6/9/2021 | | @ | Bal | L | 0-3 | | Mengden | R | Mengden | | Hill,R | L |
| 6/10/2021 | | @ | Bal | W | 4-2 | | Scherzer | R | Scherzer | Workman | Dunning | R |
| 6/11/2021 | | @ |  Bos | W | 6-5 | | Nola,Aa | R | Pagan | | Pena,Fe | R |
| 6/12/2021 | | @ | Bos | L | 5-7 | | Sanchez,Aa | R | Kittredge | | Romano,S | R |
| 6/13/2021 | | @ | Bos | W | 8-0 | | Maeda | R | Maeda | | Blach | L |
| 6/15/2021 | | @ |  Mtl | W | 5-0 | | Scherzer | R | Scherzer | | Thorpe | L |
| 6/16/2021 | | @ | Mtl | W | 7-2 | | Mengden | R | Mengden | | Anderson,Bre | L |
| 6/17/2021 | | @ | Mtl | W | 5-1 | | Nola,Aa | R | Nola,Aa | | Blackburn | R |
| 6/18/2021 | | |  Cle | L | 4-11 | | Maeda | R | Maeda | | Hendricks | R |
| 6/19/2021 | | | Cle | L | 3-4 | | Scherzer | R | Scherzer | | Honeywell | R |
| 6/20/2021 | | | Cle | L | 1-11 | | Nola,Aa | R | Nola,Aa | | Woodruff | R |
| 6/22/2021 | | |  Tor | L | 0-6 | | Sanchez,Aa | R | Sanchez,Aa | | Freeland | L |
| 6/23/2021 | | | Tor | L | 7-8 | | Mengden | R | Mengden | | Smyly | L |
| 6/24/2021 | | | Tor | W | 3-0 | | Maeda | R | Maeda | Workman | Reid-Foley | R |
| 6/25/2021 | | |  Min | W | 6-1 | | Scherzer | R | Scherzer | | Lauer | L |
| 6/26/2021 | | | Min | W | 5-4 | | Nola,Aa | R | Workman | | Paddack | R |
| 6/27/2021 | | | Min | L | 5-9 | | Sanchez,Aa | R | Sanchez,Aa | | Ray,R | L |
| 7/8/2021 | | @ |  NYM | W | 4-3 | | Kittredge | R | Pagan | | Brault | L |
| 7/8/2021 | | |  Hou | W | 5-4 | | Sanchez,Aa | R | Workman | | deGrom | R |
| 7/9/2021 | | @ | NYM | W | 4-3 | | Scherzer | R | Scherzer | Workman | Anderson,I | R |
| 7/9/2021 | | | Hou | W | 5-2 | | Nola,Aa | R | Nola,Aa | Workman | Stroman | R |
| 7/10/2021 | | @ | NYM | W | 7-2 | | Mengden | R | Mengden | | Gray,S | R |
| 7/10/2021 | | | Hou | W | 2-1 | | Scherzer | R | Givens | | Glasnow | R |
| 7/11/2021 | | @ | NYM | W | 7-3 | | Sanchez,Aa | R | Sanchez,Aa | | Gausman | R |
| 7/11/2021 | | | Hou | L | 2-10 | | Peacock,B | R | Peacock,B | | Gonzalez,G | L |
| 7/12/2021 | | | LAD | W | 9-4 | | Mengden | R | Mengden | | McKenzie | R |
| 7/12/2021 | | @ | SFG | L | 1-2 | | Nola,Aa | R | Nola,Aa | | Buehler | R |
| 7/13/2021 | | | LAD | L | 2-4 | | Sanchez,Aa | R | Sanchez,Aa | | Zimmermann,B | L |
| 7/13/2021 | | @ | SFG | W | 2-0 | | Scherzer | R | Scherzer | Pagan | Wheeler | R |
| 7/14/2021 | | | LAD | W | 8-6 | 14 | Nola,Aa | R | Givens | | Lucchesi | L |
| 7/14/2021 | | @ | SFG | L | 3-4 | 11 | Mengden | R | Pagan | | DeSclafani | R |
| 7/16/2021 | | @ |  Mia | W | 8-3 | | Nola,Aa | R | Wingenter | | Weaver | R |
| 7/16/2021 | | | Cin | L | 2-7 | | Peacock,B | R | Peacock,B | | Sandoval,Pat | L |
| 7/17/2021 | | @ | Mia | L | 3-5 | | Sanchez,Aa | R | Sanchez,Aa | | Manning | R |
| 7/17/2021 | | | Cin | L | 4-5 | | Scherzer | R | Workman | | Bauer | R |
| 7/18/2021 | | @ | Mia | W | 5-4 | | Peacock,B | R | Kittredge | Workman | Alcantara,Sa | R |
| 7/18/2021 | | | Cin | L | 2-4 | | Sanchez,Aa | R | Sanchez,Aa | | Borucki | L |
| 7/19/2021 | | @ | Mia | L | 1-2 | | Mengden | R | Mengden | | Wright,K | R |
| 7/19/2021 | | | Cin | W | 14-4 | | Mengden | R | Mengden | | Hatch | R |
| 7/27/2021 | | @ | Ari | L | 1-3 | | Nola,Aa | R | Nola,Aa | | Strasburg | R |
| 7/27/2021 | | | Col | L | 3-11 | | Mengden | R | Mengden | | Greinke | R |
| 7/28/2021 | | @ | Ari | W | 10-4 | | Kittredge | R | Kittredge | | Richards,G | R |
| 7/28/2021 | | | Col | L | 2-4 | | Peacock,B | R | Peacock,B | | Montas | R |
| 7/29/2021 | | @ | Ari | W | 8-6 | 10 | Sanchez,Aa | R | Wingenter | Pagan | Corbin | L |
| 7/29/2021 | | | Col | L | 7-8 | 12 | Alexander,TyJo | L | Pagan | | Stripling | R |
| 7/30/2021 | | @ | LAD | W | 11-5 | | Mengden | R | Mengden | Peacock,B | Musgrove | R |
| 7/30/2021 | | | SFG | L | 4-5 | | Nola,Aa | R | Pagan | | Buehler | R |
| 7/31/2021 | | @ | LAD | L | 0-1 | | Alexander,TyJo | L | Alexander,TyJo | | Lucchesi | L |
| 7/31/2021 | | | SFG | L | 5-10 | | Sanchez,Aa | R | Sanchez,Aa | | Anderson,Ty | L |
| 8/1/2021 | | @ | LAD | W | 4-1 | | Nola,Aa | R | Nola,Aa | Pagan | Zimmermann,B | L |
| 8/1/2021 | | | SFG | L | 4-8 | | Mengden | R | Mengden | | DeSclafani | R |
| 8/3/2021 | | @ | ChC | W | 6-2 | | Kittredge | R | Kittredge | | Boyd | L |
| 8/3/2021 | | | NYM | L | 3-4 | 14 | Alexander,TyJo | L | Wingenter | | Means | L |
| 8/4/2021 | | @ | ChC | L | 2-5 | | Sanchez,Aa | R | Sanchez,Aa | | Mikolas | R |
| 8/4/2021 | | | NYM | W | 7-3 | | Nola,Aa | R | Nola,Aa | | Tanaka | R |
| 8/5/2021 | | @ | ChC | W | 6-4 | 10 | Alexander,TyJo | L | Nelson,K | Pagan | Pearson | R |
| 8/5/2021 | | | NYM | W | 6-4 | | Sanchez,Aa | R | Sanchez,Aa | Kittredge | Gausman | R |
| 8/6/2021 | | @ | ChC | W | 2-1 | | Mengden | R | Mengden | Pagan | Smith,Ca | L |
| 8/6/2021 | | | NYM | L | 0-7 | | Mengden | R | Mengden | | Gray,S | R |
| 8/12/2021 | | @ | Hou | W | 6-5 | | Scherzer | R | Scherzer | Pagan | Howard,Sp | R |
| 8/12/2021 | | | Atl | L | 5-6 | | Scherzer | R | Garcia,Y | | Young,Al | L |
| 8/13/2021 | | @ | Hou | L | 6-7 | | Bundy | R | Ramos,E | | Glasnow | R |
| 8/13/2021 | | | Atl | W | 9-4 | | Bundy | R | Bundy | | Santana,De | R |
| 8/14/2021 | | @ | Hou | W | 8-6 | | Swanson,E | R | Swanson,E | | Gonzalez,G | L |
| 8/14/2021 | | | Atl | W | 4-0 | | Minor | L | Minor | | Kershaw | L |
| 8/15/2021 | | @ | Hou | L | 1-3 | | Mengden | R | Mengden | | deGrom | R |
| 8/15/2021 | | | Atl | W | 1-0 | | Nola,Aa | R | Nola,Aa | Ginkel | Soroka | R |
| 8/16/2021 | | @ | Mil | W | 3-1 | | Nola,Aa | R | Nola,Aa | | Civale | R |
| 8/16/2021 | | | Mia | L | 4-5 | 11 | Mengden | R | Kittredge | | Weaver | R |
| 8/17/2021 | | @ | Mil | W | 14-5 | | Minor | L | Minor | | Darvish | R |
| 8/17/2021 | | | Mia | W | 2-0 | | Scherzer | R | Scherzer | | Shoemaker | R |
| 8/18/2021 | | @ | Mil | W | 8-7 | | Kittredge | R | Ginkel | Pagan | Kelly,M | R |
| 8/18/2021 | | | Mia | W | 9-2 | | Bundy | R | Bundy | | Gore,M | L |
| 8/19/2021 | | @ | Mil | W | 4-2 | | Swanson,E | R | Swanson,E | Pagan | Kluber | R |
| 8/19/2021 | | | Mia | W | 7-2 | | Minor | L | Minor | | Menez | L |
| 8/31/2021 | | @ | Col | L | 4-5 | | Scherzer | R | Scherzer | | Stripling | R |
| 8/31/2021 | | | Ari | L | 0-13 | | Sanchez,Aa | R | Sanchez,Aa | | Strasburg | R |
| 9/1/2021 | | @ | Col | L | 5-6 | | Bundy | R | Ramos,E | | Lucchesi | L |
| 9/1/2021 | | | Ari | L | 2-10 | | Mengden | R | Mengden | | Paxton | L |
| 9/2/2021 | | @ | Col | L | 6-12 | | Swanson,E | R | Swanson,E | | Morton | R |
| 9/2/2021 | | | Ari | L | 2-3 | | Scherzer | R | Scherzer | | Gray,Jon | R |
| 9/3/2021 | | @ | Phi | W | 5-2 | | Minor | L | Minor | Pagan | Carrasco | R |
| 9/3/2021 | | | StL | L | 1-5 | | Minor | L | Minor | | Heaney | L |
| 9/4/2021 | | @ | Phi | L | 0-4 | | Peacock,B | R | Peacock,B | | Clevinger | R |
| 9/4/2021 | | | StL | L | 1-2 | | Bundy | R | Bundy | | Skubal | L |
| 9/5/2021 | | @ | Phi | L | 5-6 | | Swanson,E | R | Workman | | Castillo,L | R |
| 9/5/2021 | | | StL | L | 8-9 | | Sanchez,Aa | R | Bracho | | McCullers Jr. | R |
| 9/6/2021 | | @ | Phi | L | 3-9 | | Sanchez,Aa | R | Sanchez,Aa | | Bieber | R |
| 9/6/2021 | | | StL | W | 2-1 | 10 | Mengden | R | Workman | | Mize | R |
| 9/17/2021 | | | LAD | L | 1-2 | | Minor | L | Minor | | Musgrove | R |
| 9/17/2021 | | @ | SFG | W | 3-0 | | Scherzer | R | Scherzer | Workman | Urquidy | R |
| 9/18/2021 | | | LAD | W | 5-2 | | Mengden | R | Mengden | Bracho | Stewart,K | R |
| 9/18/2021 | | @ | SFG | W | 4-3 | | Nola,Aa | R | Nola,Aa | Workman | Wheeler | R |
| 9/19/2021 | | | LAD | W | 5-1 | | Peacock,B | R | Peacock,B | | Berrios | R |
| 9/19/2021 | | @ | SFG | L | 2-4 | | Bundy | R | Ginkel | | Buehler | R |
| 9/20/2021 | | @ | Ari | L | 1-7 | | Mengden | R | Mengden | | Corbin | L |
| 9/20/2021 | | | SFG | L | 1-2 | | Kittredge | R | Kittredge | | DeSclafani | R |
| 9/21/2021 | | @ | Ari | L | 2-5 | | Swanson,E | R | Kittredge | | Paxton | L |
| 9/21/2021 | | | SFG | L | 7-11 | | Nola,Aa | R | Ginkel | | Lopez,Re | R |
| Other |
| Game information | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | | W | L | Pct | L10 | Strk | Gm# |
| 3/29/2021 | | @ | Atl | W | Toro | 3 | 1 | | 1 | 0 | 1.000 | 1-0 | W1 | 1 |
| 3/29/2021 | | | ChC | W | Votto | 3 | 0 | | 2 | 0 | 1.000 | 2-0 | W2 | 2 |
| 3/30/2021 | | @ | Atl | L | | 0 | 7 | | 2 | 1 | .667 | 2-1 | L1 | 3 |
| 3/30/2021 | | | ChC | L | | 4 | 6 | | 2 | 2 | .500 | 2-2 | L2 | 4 |
| 3/31/2021 | | @ | Atl | W | Kendrick | 4 | 2 | | 3 | 2 | .600 | 3-2 | W1 | 5 |
| 3/31/2021 | | | ChC | W | Toro | 4 | 2 | | 4 | 2 | .667 | 4-2 | W2 | 6 |
| 4/1/2021 | | @ | Atl | W | Eaton | 4 | 3 | | 5 | 2 | .714 | 5-2 | W3 | 7 |
| 4/1/2021 | | | ChC | W | Kendrick | 9 | 8 | | 6 | 2 | .750 | 6-2 | W4 | 8 |
| 4/2/2021 | | @ | LAD | L | | 2 | 3 | | 6 | 3 | .667 | 6-3 | L1 | 9 |
| 4/2/2021 | | | SFG | L | | 3 | 5 | | 6 | 4 | .600 | 6-4 | L2 | 10 |
| 4/3/2021 | | @ | LAD | L | | 1 | 3 | | 6 | 5 | .545 | 5-5 | L3 | 11 |
| 4/3/2021 | | | SFG | L | | 4 | 8 | | 6 | 6 | .500 | 4-6 | L4 | 12 |
| 4/4/2021 | | @ | LAD | W | Peralta,D | 14 | 9 | | 7 | 6 | .538 | 5-5 | W1 | 13 |
| 4/4/2021 | | | SFG | L | | 0 | 1 | | 7 | 7 | .500 | 5-5 | L1 | 14 |
| 4/6/2021 | | @ | Ari | L | | 6 | 12 | | 7 | 8 | .467 | 4-6 | L2 | 15 |
| 4/6/2021 | | | Col | L | | 3 | 4 | | 7 | 9 | .438 | 3-7 | L3 | 16 |
| 4/7/2021 | | @ | Ari | W | Votto | 6 | 5 | | 8 | 9 | .471 | 3-7 | W1 | 17 |
| 4/7/2021 | | | Col | L | | 7 | 9 | | 8 | 10 | .444 | 2-8 | L1 | 18 |
| 4/8/2021 | | @ | Ari | L | | 2 | 4 | | 8 | 11 | .421 | 2-8 | L2 | 19 |
| 4/8/2021 | | | Col | L | | 0 | 1 | | 8 | 12 | .400 | 2-8 | L3 | 20 |
| 4/19/2021 | | @ | Pit | W | Votto | 4 | 3 | | 9 | 12 | .429 | 3-7 | W1 | 21 |
| 4/19/2021 | | | Mil | L | | 4 | 5 | | 9 | 13 | .409 | 3-7 | L1 | 22 |
| 4/20/2021 | | @ | Pit | W | Ramirez,J | 13 | 3 | | 10 | 13 | .435 | 3-7 | W1 | 23 |
| 4/20/2021 | | | Mil | L | | 3 | 4 | | 10 | 14 | .417 | 3-7 | L1 | 24 |
| 4/21/2021 | | @ | Pit | W | Read | 9 | 2 | | 11 | 14 | .440 | 4-6 | W1 | 25 |
| 4/21/2021 | | | Mil | L | | 3 | 6 | | 11 | 15 | .423 | 4-6 | L1 | 26 |
| 4/22/2021 | | @ | Pit | L | | 1 | 2 | | 11 | 16 | .407 | 3-7 | L2 | 27 |
| 4/22/2021 | | | Mil | L | | 4 | 5 | | 11 | 17 | .393 | 3-7 | L3 | 28 |
| 4/23/2021 | | @ | Was | W | Ramirez,J | 10 | 3 | | 12 | 17 | .414 | 4-6 | W1 | 29 |
| 4/24/2021 | | @ | Was | L | | 1 | 2 | | 12 | 18 | .400 | 4-6 | L1 | 30 |
| 4/25/2021 | | @ | Was | L | | 1 | 2 | | 12 | 19 | .387 | 3-7 | L2 | 31 |
| 4/27/2021 | | @ | NYY | W | Votto | 8 | 2 | | 13 | 19 | .406 | 4-6 | W1 | 32 |
| 4/28/2021 | | @ | NYY | W | Votto | 7 | 6 | | 14 | 19 | .424 | 4-6 | W2 | 33 |
| 4/29/2021 | | @ | NYY | L | | 4 | 6 | | 14 | 20 | .412 | 4-6 | L1 | 34 |
| 5/7/2021 | | | Det | W | Read | 10 | 4 | | 15 | 20 | .429 | 4-6 | W1 | 35 |
| 5/8/2021 | | | Det | W | Toro | 4 | 0 | | 16 | 20 | .444 | 5-5 | W2 | 36 |
| 5/9/2021 | | | Det | L | | 1 | 2 | | 16 | 21 | .432 | 5-5 | L1 | 37 |
| 5/11/2021 | | | ChW | L | | 5 | 6 | | 16 | 22 | .421 | 5-5 | L2 | 38 |
| 5/12/2021 | | | ChW | W | Toro | 4 | 3 | | 17 | 22 | .436 | 5-5 | W1 | 39 |
| 5/13/2021 | | | ChW | L | | 3 | 9 | | 17 | 23 | .425 | 5-5 | L1 | 40 |
| 5/20/2021 | | @ | Cin | L | | 3 | 5 | | 17 | 24 | .415 | 5-5 | L2 | 41 |
| 5/20/2021 | | | Pit | W | Ramirez,J | 16 | 3 | | 18 | 24 | .429 | 5-5 | W1 | 42 |
| 5/21/2021 | | @ | Cin | W | Kendrick | 8 | 5 | | 19 | 24 | .442 | 5-5 | W2 | 43 |
| 5/21/2021 | | | Pit | L | | 8 | 10 | | 19 | 25 | .432 | 5-5 | L1 | 44 |
| 5/22/2021 | | @ | Cin | L | | 6 | 12 | | 19 | 26 | .422 | 4-6 | L2 | 45 |
| 5/22/2021 | | | Pit | W | Blackmon | 2 | 1 | | 20 | 26 | .435 | 4-6 | W1 | 46 |
| 5/23/2021 | | @ | Cin | W | | 15 | 10 | | 21 | 26 | .447 | 5-5 | W2 | 47 |
| 5/23/2021 | | | Pit | W | Blackmon | 5 | 3 | | 22 | 26 | .458 | 6-4 | W3 | 48 |
| 5/24/2021 | | @ | Col | W | Peralta,D | 12 | 3 | | 23 | 26 | .469 | 6-4 | W4 | 49 |
| 5/24/2021 | | | Ari | W | Kendrick | 1 | 0 | | 24 | 26 | .480 | 7-3 | W5 | 50 |
| 5/25/2021 | | @ | Col | L | | 4 | 9 | | 24 | 27 | .471 | 7-3 | L1 | 51 |
| 5/25/2021 | | | Ari | W | Frazier,T | 6 | 1 | | 25 | 27 | .481 | 7-3 | W1 | 52 |
| 5/26/2021 | | @ | Col | W | Ramirez,J | 9 | 4 | | 26 | 27 | .491 | 7-3 | W2 | 53 |
| 5/26/2021 | | | Ari | L | | 9 | 16 | | 26 | 28 | .481 | 7-3 | L1 | 54 |
| 5/28/2021 | | @ | StL | W | Peralta,D | 7 | 6 | | 27 | 28 | .491 | 8-2 | W1 | 55 |
| 5/28/2021 | | | Phi | W | Eaton | 6 | 2 | | 28 | 28 | .500 | 8-2 | W2 | 56 |
| 5/29/2021 | | @ | StL | L | | 2 | 7 | | 28 | 29 | .491 | 7-3 | L1 | 57 |
| 5/29/2021 | | | Phi | L | | 2 | 6 | | 28 | 30 | .483 | 6-4 | L2 | 58 |
| 5/30/2021 | | @ | StL | W | Votto | 11 | 3 | | 29 | 30 | .492 | 6-4 | W1 | 59 |
| 5/30/2021 | | | Phi | W | Blackmon | 5 | 3 | | 30 | 30 | .500 | 6-4 | W2 | 60 |
| 5/31/2021 | | @ | StL | W | Kendrick | 9 | 4 | | 31 | 30 | .508 | 7-3 | W3 | 61 |
| 5/31/2021 | | | Phi | L | | 7 | 8 | | 31 | 31 | .500 | 6-4 | L1 | 62 |
| 6/8/2021 | | @ | Bal | W | Read | 7 | 1 | | 32 | 31 | .508 | 6-4 | W1 | 63 |
| 6/9/2021 | | @ | Bal | L | | 0 | 3 | | 32 | 32 | .500 | 6-4 | L1 | 64 |
| 6/10/2021 | | @ | Bal | W | Ramirez,J | 4 | 2 | | 33 | 32 | .508 | 6-4 | W1 | 65 |
| 6/11/2021 | | @ | Bos | W | Markakis | 6 | 5 | | 34 | 32 | .515 | 6-4 | W2 | 66 |
| 6/12/2021 | | @ | Bos | L | | 5 | 7 | | 34 | 33 | .507 | 6-4 | L1 | 67 |
| 6/13/2021 | | @ | Bos | W | Cain | 8 | 0 | | 35 | 33 | .515 | 7-3 | W1 | 68 |
| 6/15/2021 | | @ | Mtl | W | Frazier,T | 5 | 0 | | 36 | 33 | .522 | 7-3 | W2 | 69 |
| 6/16/2021 | | @ | Mtl | W | | 7 | 2 | | 37 | 33 | .529 | 7-3 | W3 | 70 |
| 6/17/2021 | | @ | Mtl | W | Votto | 5 | 1 | | 38 | 33 | .535 | 7-3 | W4 | 71 |
| 6/18/2021 | | | Cle | L | | 4 | 11 | | 38 | 34 | .528 | 7-3 | L1 | 72 |
| 6/19/2021 | | | Cle | L | | 3 | 4 | | 38 | 35 | .521 | 6-4 | L2 | 73 |
| 6/20/2021 | | | Cle | L | | 1 | 11 | | 38 | 36 | .514 | 6-4 | L3 | 74 |
| 6/22/2021 | | | Tor | L | | 0 | 6 | | 38 | 37 | .507 | 5-5 | L4 | 75 |
| 6/23/2021 | | | Tor | L | | 7 | 8 | | 38 | 38 | .500 | 4-6 | L5 | 76 |
| 6/24/2021 | | | Tor | W | Blackmon | 3 | 0 | | 39 | 38 | .506 | 5-5 | W1 | 77 |
| 6/25/2021 | | | Min | W | Votto | 6 | 1 | | 40 | 38 | .513 | 5-5 | W2 | 78 |
| 6/26/2021 | | | Min | W | Votto | 5 | 4 | | 41 | 38 | .519 | 5-5 | W3 | 79 |
| 6/27/2021 | | | Min | L | | 5 | 9 | | 41 | 39 | .512 | 4-6 | L1 | 80 |
| 7/8/2021 | | @ | NYM | W | Blackmon | 4 | 3 | | 42 | 39 | .519 | 4-6 | W1 | 81 |
| 7/8/2021 | | | Hou | W | Kendrick | 5 | 4 | | 43 | 39 | .524 | 5-5 | W2 | 82 |
| 7/9/2021 | | @ | NYM | W | Eaton | 4 | 3 | | 44 | 39 | .530 | 6-4 | W3 | 83 |
| 7/9/2021 | | | Hou | W | Ramirez,J | 5 | 2 | | 45 | 39 | .536 | 7-3 | W4 | 84 |
| 7/10/2021 | | @ | NYM | W | Holt | 7 | 2 | | 46 | 39 | .541 | 8-2 | W5 | 85 |
| 7/10/2021 | | | Hou | W | Toro | 2 | 1 | | 47 | 39 | .547 | 9-1 | W6 | 86 |
| 7/11/2021 | | @ | NYM | W | Ramirez,J | 7 | 3 | | 48 | 39 | .552 | 9-1 | W7 | 87 |
| 7/11/2021 | | | Hou | L | | 2 | 10 | | 48 | 40 | .545 | 8-2 | L1 | 88 |
| 7/12/2021 | | | LAD | W | Ramirez,J | 9 | 4 | | 49 | 40 | .551 | 8-2 | W1 | 89 |
| 7/12/2021 | | @ | SFG | L | | 1 | 2 | | 49 | 41 | .544 | 8-2 | L1 | 90 |
| 7/13/2021 | | | LAD | L | | 2 | 4 | | 49 | 42 | .538 | 7-3 | L2 | 91 |
| 7/13/2021 | | @ | SFG | W | Kendrick | 2 | 0 | | 50 | 42 | .543 | 7-3 | W1 | 92 |
| 7/14/2021 | | | LAD | W | Eaton | 8 | 6 | | 51 | 42 | .548 | 7-3 | W2 | 93 |
| 7/14/2021 | | @ | SFG | L | | 3 | 4 | | 51 | 43 | .543 | 6-4 | L1 | 94 |
| 7/16/2021 | | @ | Mia | W | Blackmon | 8 | 3 | | 52 | 43 | .547 | 6-4 | W1 | 95 |
| 7/16/2021 | | | Cin | L | | 2 | 7 | | 52 | 44 | .542 | 5-5 | L1 | 96 |
| 7/17/2021 | | @ | Mia | L | | 3 | 5 | | 52 | 45 | .536 | 4-6 | L2 | 97 |
| 7/17/2021 | | | Cin | L | | 4 | 5 | | 52 | 46 | .531 | 4-6 | L3 | 98 |
| 7/18/2021 | | @ | Mia | W | Read | 5 | 4 | | 53 | 46 | .535 | 4-6 | W1 | 99 |
| 7/18/2021 | | | Cin | L | | 2 | 4 | | 53 | 47 | .530 | 4-6 | L1 | 100 |
| 7/19/2021 | | @ | Mia | L | | 1 | 2 | | 53 | 48 | .525 | 4-6 | L2 | 101 |
| 7/19/2021 | | | Cin | W | Ramirez,J | 14 | 4 | | 54 | 48 | .529 | 4-6 | W1 | 102 |
| 7/27/2021 | | @ | Ari | L | | 1 | 3 | | 54 | 49 | .524 | 3-7 | L1 | 103 |
| 7/27/2021 | | | Col | L | | 3 | 11 | | 54 | 50 | .519 | 3-7 | L2 | 104 |
| 7/28/2021 | | @ | Ari | W | Peralta,D | 10 | 4 | | 55 | 50 | .524 | 3-7 | W1 | 105 |
| 7/28/2021 | | | Col | L | | 2 | 4 | | 55 | 51 | .519 | 3-7 | L1 | 106 |
| 7/29/2021 | | @ | Ari | W | Peralta,D | 8 | 6 | | 56 | 51 | .523 | 4-6 | W1 | 107 |
| 7/29/2021 | | | Col | L | | 7 | 8 | | 56 | 52 | .519 | 4-6 | L1 | 108 |
| 7/30/2021 | | @ | LAD | W | Blackmon | 11 | 5 | | 57 | 52 | .523 | 4-6 | W1 | 109 |
| 7/30/2021 | | | SFG | L | | 4 | 5 | | 57 | 53 | .518 | 4-6 | L1 | 110 |
| 7/31/2021 | | @ | LAD | L | | 0 | 1 | | 57 | 54 | .514 | 4-6 | L2 | 111 |
| 7/31/2021 | | | SFG | L | | 5 | 10 | | 57 | 55 | .509 | 3-7 | L3 | 112 |
| 8/1/2021 | | @ | LAD | W | Ramirez,J | 4 | 1 | | 58 | 55 | .513 | 4-6 | W1 | 113 |
| 8/1/2021 | | | SFG | L | | 4 | 8 | | 58 | 56 | .509 | 4-6 | L1 | 114 |
| 8/3/2021 | | @ | ChC | W | | 6 | 2 | | 59 | 56 | .513 | 4-6 | W1 | 115 |
| 8/3/2021 | | | NYM | L | | 3 | 4 | | 59 | 57 | .509 | 4-6 | L1 | 116 |
| 8/4/2021 | | @ | ChC | L | | 2 | 5 | | 59 | 58 | .504 | 3-7 | L2 | 117 |
| 8/4/2021 | | | NYM | W | Cain | 7 | 3 | | 60 | 58 | .508 | 4-6 | W1 | 118 |
| 8/5/2021 | | @ | ChC | W | Votto | 6 | 4 | | 61 | 58 | .513 | 4-6 | W2 | 119 |
| 8/5/2021 | | | NYM | W | Cain | 6 | 4 | | 62 | 58 | .517 | 5-5 | W3 | 120 |
| 8/6/2021 | | @ | ChC | W | Eaton | 2 | 1 | | 63 | 58 | .521 | 6-4 | W4 | 121 |
| 8/6/2021 | | | NYM | L | | 0 | 7 | | 63 | 59 | .516 | 6-4 | L1 | 122 |
| 8/12/2021 | | @ | Hou | W | Eaton | 6 | 5 | | 64 | 59 | .520 | 6-4 | W1 | 123 |
| 8/12/2021 | | | Atl | L | | 5 | 6 | | 64 | 60 | .516 | 6-4 | L1 | 124 |
| 8/13/2021 | | @ | Hou | L | | 6 | 7 | | 64 | 61 | .512 | 5-5 | L2 | 125 |
| 8/13/2021 | | | Atl | W | Chirinos,R | 9 | 4 | | 65 | 61 | .516 | 6-4 | W1 | 126 |
| 8/14/2021 | | @ | Hou | W | Thames | 8 | 6 | | 66 | 61 | .520 | 7-3 | W2 | 127 |
| 8/14/2021 | | | Atl | W | Castro,W | 4 | 0 | | 67 | 61 | .523 | 7-3 | W3 | 128 |
| 8/15/2021 | | @ | Hou | L | | 1 | 3 | | 67 | 62 | .519 | 6-4 | L1 | 129 |
| 8/15/2021 | | | Atl | W | Blackmon | 1 | 0 | | 68 | 62 | .523 | 6-4 | W1 | 130 |
| 8/16/2021 | | @ | Mil | W | Castro,W | 3 | 1 | | 69 | 62 | .527 | 6-4 | W2 | 131 |
| 8/16/2021 | | | Mia | L | | 4 | 5 | | 69 | 63 | .523 | 6-4 | L1 | 132 |
| 8/17/2021 | | @ | Mil | W | Santana,Ca | 14 | 5 | | 70 | 63 | .526 | 6-4 | W1 | 133 |
| 8/17/2021 | | | Mia | W | Santana,Ca | 2 | 0 | | 71 | 63 | .530 | 7-3 | W2 | 134 |
| 8/18/2021 | | @ | Mil | W | Castro,W | 8 | 7 | | 72 | 63 | .533 | 8-2 | W3 | 135 |
| 8/18/2021 | | | Mia | W | Odor | 9 | 2 | | 73 | 63 | .537 | 8-2 | W4 | 136 |
| 8/19/2021 | | @ | Mil | W | Vogelbach | 4 | 2 | | 74 | 63 | .540 | 8-2 | W5 | 137 |
| 8/19/2021 | | | Mia | W | Votto | 7 | 2 | | 75 | 63 | .543 | 8-2 | W6 | 138 |
| 8/31/2021 | | @ | Col | L | | 4 | 5 | | 75 | 64 | .540 | 8-2 | L1 | 139 |
| 8/31/2021 | | | Ari | L | | 0 | 13 | | 75 | 65 | .536 | 7-3 | L2 | 140 |
| 9/1/2021 | | @ | Col | L | | 5 | 6 | | 75 | 66 | .532 | 6-4 | L3 | 141 |
| 9/1/2021 | | | Ari | L | | 2 | 10 | | 75 | 67 | .528 | 6-4 | L4 | 142 |
| 9/2/2021 | | @ | Col | L | | 6 | 12 | | 75 | 68 | .524 | 5-5 | L5 | 143 |
| 9/2/2021 | | | Ari | L | | 2 | 3 | | 75 | 69 | .521 | 4-6 | L6 | 144 |
| 9/3/2021 | | @ | Phi | W | Santana,Ca | 5 | 2 | | 76 | 69 | .524 | 4-6 | W1 | 145 |
| 9/3/2021 | | | StL | L | | 1 | 5 | | 76 | 70 | .521 | 3-7 | L1 | 146 |
| 9/4/2021 | | @ | Phi | L | | 0 | 4 | | 76 | 71 | .517 | 2-8 | L2 | 147 |
| 9/4/2021 | | | StL | L | | 1 | 2 | | 76 | 72 | .514 | 1-9 | L3 | 148 |
| 9/5/2021 | | @ | Phi | L | | 5 | 6 | | 76 | 73 | .510 | 1-9 | L4 | 149 |
| 9/5/2021 | | | StL | L | | 8 | 9 | | 76 | 74 | .507 | 1-9 | L5 | 150 |
| 9/6/2021 | | @ | Phi | L | | 3 | 9 | | 76 | 75 | .503 | 1-9 | L6 | 151 |
| 9/6/2021 | | | StL | W | Chirinos,R | 2 | 1 | | 77 | 75 | .507 | 2-8 | W1 | 152 |
| 9/17/2021 | | | LAD | L | | 1 | 2 | | 77 | 76 | .503 | 2-8 | L1 | 153 |
| 9/17/2021 | | @ | SFG | W | Chirinos,R | 3 | 0 | | 78 | 76 | .506 | 3-7 | W1 | 154 |
| 9/18/2021 | | | LAD | W | Castro,W | 5 | 2 | | 79 | 76 | .510 | 3-7 | W2 | 155 |
| 9/18/2021 | | @ | SFG | W | Thames | 4 | 3 | | 80 | 76 | .513 | 4-6 | W3 | 156 |
| 9/19/2021 | | | LAD | W | Cain | 5 | 1 | | 81 | 76 | .516 | 5-5 | W4 | 157 |
| 9/19/2021 | | @ | SFG | L | | 2 | 4 | | 81 | 77 | .513 | 5-5 | L1 | 158 |
| 9/20/2021 | | @ | Ari | L | | 1 | 7 | | 81 | 78 | .509 | 5-5 | L2 | 159 |
| 9/20/2021 | | | SFG | L | | 1 | 2 | | 81 | 79 | .506 | 5-5 | L3 | 160 |
| 9/21/2021 | | @ | Ari | L | | 2 | 5 | | 81 | 80 | .503 | 5-5 | L4 | 161 |
| 9/21/2021 | | | SFG | L | | 7 | 11 | | 81 | 81 | .500 | 4-6 | L5 | 162 |