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| Most hits in one game | ||||
| Record | Date | Player | Inn | Site |
| 6 | 8/17/2020 | Dee Gordon, Cin | 9 |  |
| 6 | 6/8/2019 | Lorenzo Cain, Mtl | 10 |  |
| 6 | 2017 | Hernan Perez, Phi | 9 | |
| 6 | 2017 | Ryan Braun, Col | 8.5 | |
| 6 | 2014 | Joaquin Arias, Pit (14); Omar Infante, Det | 9 | |
| 6 | 2013 | Robinson Cano, Sea | 9 | |
| 6 | 2012 | David Ortiz, ChW | 12 | |
| 6 | 2011 | Reggie Willits, Ari | 10 | |
| 6 | 2010 | Matt Wieters, Bal; Rajai Davis, LAD | 9 | |
| 6 | 2009 | Ichiro Suzuki, Ari; Akinori Iwamura, Bal | 9 | |
| 6 | 2008 | Gary Matthews, SD; Aaron Rowand, ChC | 9 | |
| 6 | 2007 | Joe Crede, Mil; Ray Durham, Bos; Ichiro Suzuki, Ari | 9 | |
| 6 | 2006 | Bernie Williams, NYY; Jeff Kent, Col | 9 | |
| Most runs in one game | ||||
| Record | Date | Player | Inn | Site |
| 6 | 9/7/2014 | Jayson Werth, Oakland 18, Los Angeles AL 5 | 9 |  |
| 6 | 5/15/2009 | Ramon Santiago, Los Angeles NL 22, Atlanta 2 | 9 |  |
| 6 | 4/24/2006 | Luis Castillo, Seattle 9, New York NL 0 | 9 |  |
| 6 | 9/20/2008 | J.J. Hardy, Atlanta 12, Pittsburgh 13 | 14 | |
| Most singles in one game | ||||
| Record | Date | Player | Inn | Site |
| 6 | 8/17/2020 | Dee Gordon, Cin | 9 | |
| 6 | 4/17/2010 | Matt Wieters, Baltimore 14, Texas 7 | 9 |  |
| 5 | 73 times | Any | ||
| Most doubles in one game | ||||
| Record | Date | Player | Inn | Site |
| 4 | 15 times | 9 | ||
| 3 | Multiple times | Extras | ||
| Most triples in one game | ||||
| Record | Date | Player | Inn | Site |
| 3 | 5/29/2016 | Billy Burns, Arizona 5, Chicago NL 4 | 9 |  |
| 3 | 5/13/2012 | Dexter Fowler, Chicago NL 2, Baltimore 1 | 8.5 | |
| 3 | 9/5/2012 | Mike Fontenot, Texas 3, Kansas City 1 | 9 |  |
| 2 | Multiple times | Extras | ||
| Most home runs in one game | ||||
| Record | Date | Player | Inn | Site |
| 4 | 5/28/2021 | Bryce Harper, Chicago AL 8, Toronto 13 | 9 |  |
| 4 | 8/6/2018 | Aaron Judge, Toronto 12, Detroit 0 | 8 | |
| 4 | 8/3/2018 | Eddie Rosario, San Diego 7, New York NL 11 | 9 |  |
| 4 | 8/24/2017 | Brandon Moss, Texas 7, Cleveland 4 | 9 |  |
| 4 | 9/5/2015 | Adam Duvall, Cincinnati 5, Houston 4 | 9 |  |
| 4 | 5/28/2011 | Aramis Ramirez, New York NL 12, Cincinnati 4 | 9 |  |
| 4 | 4/11/2008 | Lance Berkman, Philadelphia 9, Florida 6 | 9 |  |
| 4 | 4/12/2007 | Eric Byrnes, Cincinnati 12, Chicago NL 5 | 9 | |
| 4 | 9/26/2006 | David Dellucci, Philadelphia 17, Houston 6 | 9 |  |
| Most grand slams in one game | ||||
| Record | Date | Player | Inn | Site |
| 2 | 8/11/2014 | Adam Jones, Chicago NL 8, New York NL 4 | 9 | |
| 2 | 4/5/2011 | Mark Reynolds, St. Louis 15, Houston 4 | 9 | |
| 2 | 5/24/2006 | John Olerud, Baltimore 15, New York AL 8 | 9 |  |
| Most RBI in one game | ||||
| Record | Date | Player | Inn | Site |
| 10 | 8/6/2017 | Victor Martinez, Texas 12, Kansas City 7 | 9 | |
| 10 | 8/3/2007 | Brad Wilkerson, San Francisco 22, Arizona 3 | 9 |  |
| 7 | Five times | Extras | ||
| Most total bases in one game | ||||
| Record | Date | Player | Inn | Site |
| 17 | 5/28/2021 | Bryce Harper, Chicago AL 8, Toronto 13 | 8.5 | |
| 17 | 8/6/2018 | Aaron Judge, Toronto 12, Detroit 0 | 8 | |
| 16 | 8/3/2018 | Eddie Rosario, San Diego 7, New York NL 11 | 9 | |
| 16 | 8/24/2017 | Brandon Moss, Texas 7, Cleveland 4 | 9 | |
| 16 | 5/10/2017 | Brad Miller, Cincinnati 13, Oakland 5 | 8.5 | |
| 16 | 9/5/2015 | Adam Duvall, Cincinnati 5, Houston 4 | 9 | |
| 16 | 5/28/2011 | Aramis Ramirez, New York NL 12, Cincinnati 4 | 9 | |
| 16 | 6/12/2011 | Carlos Ruiz, Boston 9, Los Angeles AL 6 | 9 |  |
| 16 | 4/11/2008 | Lance Berkman, Philadelphia 9, Florida 6 | 9 | |
| 16 | 4/12/2007 | Eric Byrnes, Cincinnati 12, Chicago NL 5 | 9 | |
| 16 | 9/26/2006 | David Dellucci, Philadelphia 17, Houston 6 | 9 | |
| 16 | 9/15/2006 | Preston Wilson, Washington 22, Kansas City 9 | 9 |  |
| Most stolen bases in one game | ||||
| Record | Date | Player | Inn | Site |
| 5 | 8/7/2020 | Garrett Hampson, ChC | 8.5 |  |
| 5 | 2 times | Extras | ||
| Most caught stealing in one game | ||||
| Record | Date | Player | Inn | Site |
| 3 | 8/18/2011 | Brett Gardner, Atlanta 5, Cincinnati 7 | 9 | |
| 2 | 54 times | Extras | ||
| Most at-bats in one game | ||||
| Record | Date | Player | Inn | Site |
| 8 | 7/24/2010 | Felipe Lopez, Los Angeles NL 32, Colorado 3 | 9 |  |
| 8 | 5/24/2008 | Omar Infante, Cleveland 21, Washington 0 | 9 | |
| 11 | 5/16/2019 | Javier Baez, Miami 7, Milwaukee 6 | 23 |  |
| Most strikeouts in one game | ||||
| Record | Date | Player | Inn | Site |
| 6 | 8/15/2020 | Wil Myers, Los Angeles AL 9, Baltimore 7 | 9 |  |
| 6 | 9/28/2006 | Brandon Phillips, Pittsburgh 11, New York NL 4 | 9 | |
| 6 | Multiple times | Extras | ||
| Most walks in one game | ||||
| Record | Date | Player | Inn | Site |
| 5 | 10 times | 9 | ||
| 5 | Four times | Extras | ||
| Most intentional walks in one game | ||||
| Record | Date | Player | Inn | Site |
| 5 | Five times | 9 | ||
| 4 | 6/23/2012 | Andre Ethier, Chicago AL 1, Arizona 2 | 14 |  |
| Most sacrifice hits in one game | ||||
| Record | Date | Player | Inn | Site |
| 3 | 19 times | 9 | ||
| 3 | One time | Extras | ||
| Most squeeze bunts, career | ||||
| Record | Date | Player | Inn | Site |
| 8 | Coco Crisp | |||
| 6 | Clayton Kershaw, Frank Catalanotto | |||
| 5 | Brett Gardner | |||
| Most sacrifice flies in one game | ||||
| Record | Date | Player | Inn | Site |
| 3 | 8/16/2009 | Aramis Ramirez, New York NL 6, Milwaukee 0 | 8.5 | |
| Most times hit by pitch | ||||
| Record | Date | Player | Inn | Site |
| 3 | Nine times | 9 | ||
| 3 | Three times | Extras | ||
| Most at-bats in a season, no hits | ||||
| Record | Year | Player | ||
| 21 | 2011 | Hank Conger, St. Louis | ||
| 21 | 2006 | Kenny Kelly, Pittsburgh | ||
| 19 | 2006 | Shin-Soo Choo, Atlanta | ||
| 18 | 2007 | Joaquin Arias, Kansas City | ||
| 18 | 2013 | Jerry Sands, Los Angeles NL | ||
| 18 | 2019 | Chris Shaw, Miami | ||
| Record | Year | Pitcher | ||
| 33 | 2010 | Derek Holland, Florida | ||
| 30 | 2015 | Aaron Harang, Atlanta | ||
| 27 | 2011 | Derek Holland, Florida; Luis Atilano, Los Angeles NL | ||
| Most batters hit by pitcher | ||||
| Record | Date | Player | Inn | Site |
| 5 | 9/5/2012 | Brian Gordon, Seattle 2, Oakland 3 | 9 |  |
| 5 | 6/3/2008 | Luis Mendoza, Cincinnati 4, Detroit 2 | 9 |  |
| Most hits allowed in one game | ||||
| Record | Date | Player | Inn | Site |
| 30 | 7/24/2010 | Manny Parra, Colorado 3, Los Angeles NL 32 | 9 | |
| 22 | 4/11/2006 | Jon Lieber, Milwaukee 1, Philadelphia 26 | 8.5 |  |
| (After 150-pitch rule change) | ||||
| 21 | 8/16/2013 | Randy Wolf, Colorado 1, Milwaukee 15 | 8 | |
| 20 | 5/27/2015 | Christian Bergman, Colorado 3, San Diego 24 | 8 | |
| 20 | 6/16/2013 | Ian Kennedy, Colorado 9, Cleveland 20 | 8 |  |
| Most runs allowed in one game | ||||
| Record | Date | Player | Inn | Site |
| 32 | 7/24/2010 | Manny Parra, Colorado 3, Los Angeles NL 32 | 9 | |
| 26 | 4/11/2006 | Jon Lieber, Milwaukee 1, Philadelphia 26 | 8.5 | |
| (After 150-pitch rule change) | ||||
| 22 | 5/27/2015 | Christian Bergman, Colorado 3, San Diego 24 | 8 | |
| 20 | Three times | |||
| Most earned runs allowed in one game | ||||
| Record | Date | Player | Inn | Site |
| 32 | 7/24/2010 | Manny Parra, Colorado 3, Los Angeles NL 32 | 9 | |
| 25 | 4/11/2006 | Jon Lieber, Milwaukee 1, Philadelphia 26 | 8.5 | |
| (After 150-pitch rule change) | ||||
| 20 | 6/16/2013 | Ian Kennedy, Colorado 9, Cleveland 20 | 8 | |
| 19 | 9/4/2014 | Jeremy Bonderman, Miami 0, Milwaukee 20 | 8 | |
| Most walks allowed in one game | ||||
| Record | Date | Player | Inn | Site |
| 18 | 4/25/2006 | Hideo Nomo, Boston 2, Chicago NL 18 | 9 | |
| (After 150-pitch rule change) | ||||
| 12 | 9/26/2017 | Trevor Bauer, Minesota 8, Chicago AL 16 | 8.5 |  |
| 11 | Four times | |||
| Most intentional walks allowed in one game | ||||
| Record | Date | Player | Inn | Site |
| 4 | Matt Guerrier, NYM, 2007; Garrett Olson, LAA, 2008; | |||
| 4 | Tim Hudson, Chw, 2016; Ariel Jurado, NYM, 2019; | |||
| 4 | Mike Leake, NYM, 2019 | |||
| Most home runs allowed in one game | ||||
| Record | Date | Player | Inn | Site |
| 8 | 5/18/2019 | Andrew Cashner, Cincinnati 5, Colorado 15 | 8.5 |  |
| 7 | 6/3/2016 | Marco Estrada, Chicago AL 1, Los Angeles AL 11 | 9 | |
| 7 | 9/4/2014 | Aaron Harang, San Diego 0, New York NL 14 | 8 | |
| 7 | 8/16/2013 | Randy Wolf, Colorado 1, Milwaukee 15 | 8 | |
| 7 | 8/21/2006 | Kerry Wood, Montreal 13, Seattle 11 | 4 | |
| Most batters struck out in one game | ||||
| Record | Date | Player | Inn | Site |
| 17 | 6/2/2020 | Gerrit Cole, Oakland 0, Seattle 4 | 8.5 | |
| 17 | 5/30/2020 | CC Sabathia, Oakland 8, Montreal 2 | 9 | |
| 17 | 9/20/2019 | Luis Severino, New York AL 3, Toronto 0 | 9 | |
| 17 | 6/2/2018 | Alex Wood, Toronto 2, New York AL 1 | 9 | |
| 17 | 7/28/2017 | Rich Hill, Chicago AL 8, Montreal 1 | 9 | |
| 17 | 6/26/2011 | Tim Lincecum, Arizona 2, Washington 1 | 9 | |
| 16 | 13 times | |||
| Most pitches in one game | |||||
| Record | Date | Player | Inn | Site | Game Score |
| 234 | 7/24/2010 | Manny Parra, Colorado 3, Los Angeles NL 32 | 9 | | -120 |
| 214 | 4/11/2006 | Jon Lieber, Milwaukee 1, Philadelphia 26 | 8.5 | | -70 |
| Explanation of the Bill James Game Score | |||||
| Fewest pitches in one game by a starting pitcher | ||||
| Record | Date | Player | Inn | Site |
| 1 | Seven times | 9 | ||
| Fewest pitches thrown in a complete game | ||||
| Record | Date | Player | Inn | Site |
| 76 | 4/6/2014 | Mike Leake, New York NL 6, Pittsburgh 0 (no-hitter) | 9 | |
| 76 | 9/26/2009 | John Lackey, Cleveland 5, Toronto 0 | 9 | |
| 67 | 7/28/2006 | Carlos Silva, Chicago NL 0, St. Louis 2 | 8 |  |
| Most pitches thrown in relief | ||||
| Record | Date | Player | Inn | Site |
| 150 | 9/26/2017 | Trevor Bauer, Minnesota 8, Chicago AL 16 | 8.5 | |
| 147 | 8/10/2020 | Jaime Schultz, Minnesota 6, Chicago AL 15 | 8.5 | |
| 133 | 8/29/2010 | Zach Miner, Detroit 5, Baltimore 22 | 9 | |
| Most strikes in one game | ||||
| Record | Date | Player | Inn | Site |
| 111 | 7/24/2010 | Manny Parra, Colorado 3, Los Angeles NL 32 | 9 | |
| 110 | 6/10/2006 | Tim Hudson, Detroit 5, Colorado 6 | 11 | |
| 103 | 8/15/2007 | Homer Bailey, Toronto 7, Texas 1 | 9 | |
| 103 | 4/29/2007 | Horacio Ramirez, Texas 16, Montreal 2 | 9 | |
| Highest strike percentage in one game | ||||
| Record | Date | Player | Inn | Site |
| 85.1 | 7/28/2006 | Carlos Silva, Chicago NL 0, St. Louis 2 | 9 | |
| Most batters faced in one game | ||||
| Record | Date | Player | Inn | Site |
| 61 | 7/24/2010 | Manny Parra, Colorado 3, Los Angeles NL 32 | 9 | |
| 58 | 4/11/2006 | Jon Lieber, Milwaukee 1, Philadelphia 26 | 8.5 | |
| (After 150-pitch rule change) | ||||
| 51 | 8/14/2012 | Zach Duke, Florida 1, San Francisco 14 | 8 | |
| 50 | 5/27/2015 | Christian Bergman, Colorado 3, San Diego 24 | 8 | |
| 50 | 9/4/2014 | Jeremy Bonderman, Miami 0, Milwaukee 20 | 8.5 | |
| Most wild pitches in one game | ||||
| Record | Date | Player | Inn | Site |
| 5 | 5/3/2019 | Trevor Bauer, Minnesota 8, Montreal 0 | 8.5 |  |
| 5 | 9/13/2009 | Dontrelle Willis, Washington 1, Minnesota 10 | 9 | |
| Most innings pitched in one game | ||||
| Record | Date | Player | Inn | Site |
| 11 | 9/10/2013 | Erasmo Ramirez, Oakland 3, Montreal 2 | 15 | |
| 11 | 7/20/2006 | Johan Santana, Seattle 3, New York AL 2 | 20 | |
| Most double plays induced in one game | ||||
| Record | Date | Player | Inn | Site |
| 6 | Five times | 9 | ||
| Most games in a season, no decisions | ||
| Record | Year | Player |
| 57 | 2011 | Pedro Feliciano, Cleveland |
| 56 | 2007 | Akinori Otsuka, Pittsburgh |
| Most games in a season, no saves | ||
| Record | Year | Player |
| 75 | 2008 | Cla Meredith, Atlanta |
| 71 | 2017 | Carlos Torres, Colorado |
| 70 | 2020 | Pedro Baez, Seattle |
| Most games in a season, no decisions or saves | ||
| Record | Year | Player |
| 57 | 2011 | Pedro Feliciano, Cleveland |
| 45 | 2009 | Logan Kensing, Was-Col |
| Most victories in a season, no losses | ||
| Record | Year | Player |
| 13-0 | 2013 | A.J. Griffin, Atlanta |
| 11-0 | 2016 | Brad Boxberger, Kansas City |
| 11-0 | 2007 | Joe Nathan, Washington |
| 9-0 | 2012 | Jason Isringhausen, Sea |
| 9-0 | 2009 | Joey Devine, Bos |
| Most losses in a season, no victories | ||
| Record | Year | Player |
| 0-16 | 2018 | Bronson Arroyo, Washington |
| 0-15 | 2010 | Felipe Paulino, Milwaukee |
| 0-11 | 2017 | Chris Young, San Francisco |
| 0-11 | 2014 | Brandon Morrow, New York AL |
| 0-9 | 2009 | Tom Glavine, Phi-Mil |
| 0-9 | 2007 | Brian Stokes, Oakland |
| 0-9 | 2006 | Denny Bautista, San Francisco |
| Most no-decisions in a season | ||
| Record | Year | Player |
| 19 | 2006 | Kirk Saarloos, Cincinnati |
| 18 | 2011 | Ubaldo Jimenez, Arizona |
| 18 | 2020 | Wade Miley, Toronto |
| Most decisions in a season, relief pitching only | ||
| Record | Year | Player |
| 22 (5-17) | 2008 | Billy Wagner, Boston |
| 21 (9-12) | 2015 | Adam Warren, Baltimore |
| Most victories in a season, relief pitching only | ||
| Record | Year | Player |
| 15-5 | 2006 | Juan Rincon, Cincinnati |
| 13-1 | 2011 | Hong-Chih Kuo, Los Angeles NL |
| 13-2 | 2009 | Rafael Perez, New York NL |
| 13-2 | 2007 | Chad Qualls, Milwaukee |
| 13-3 | 2010 | Brandon Lyon, New York NL |
| Most losses in a season, relief pitching only | ||
| Record | Year | Player |
| 5-17 | 2008 | Billy Wagner, Boston |
| 6-14 | 2008 | Cla Meredith, Atlanta |
| Most innings in a season, 0.00 ERA | ||
| Record | Year | Player |
| 40.0 | 2017 | Ryan Merritt, Los Angeles NL |
| 25.1 | 2015 | Chris Withrow, Chicago AL |
| 21.0 | 2014 | Louis Coleman, Oakland |
| Most consecutive innings without a home run allowed | ||
| Record | Years | Player |
| 152.1 (est.) | 2006-09 | George Sherrill, Kansas City |
| Highest and lowest pitching game scores | ||||
| Record | Date | Player | Inn | Site |
| 99 | 7/19/2015 | Jake Odorizzi, Philadelphia 2, Arizona 0 | 9 |  |
| 98 | 8/21/2011 | Carlos Zambrano, Los Angeles NL 1, St. Louis 0 | 9 | |
| 97 | 9/6/2009 | Javier Vazquez, Houston 3, Philadelphia 0 | 9 | |
| 97 | 9/1/2008 | Buddy Carlyle, Los Angeles AL 3, Baltimore 0 | 9 | |
| -120 | 7/24/2010 | Manny Parra, Colorado 3, Los Angeles NL 32 | 9 | |
| -70 | 4/11/2006 | Jon Lieber, Milwaukee 1, Philadelphia 26 | 8.5 | |
| Explanation of the Bill James Game Score | ||||
| Most stolen bases allowed by catcher in one game | ||||
| Record | Date | Player | Inn | Site |
| 11 | 6/24/2013 | Jesus Montero, Pittsburgh 8, New York AL 7 | 11 | |
| 7 | Seven times | |||
| Most caught stealing by catcher in one game | ||||
| Record | Date | Player | Inn | Site |
| 6 | 5/5/2006 | Jason Varitek, Montreal 5, San Diego 4 | 9 | |
| Most passed balls in one game | ||||
| Record | Date | Player | Inn | Site |
| 4 | 4/5/2017 | Josh Thole, Colorado 5, Los Angeles NL 6 | 8.5 | |
| 3 | 11 times | 9 | ||
| Most putouts in one game | ||||
| Record | Date | Player | Inn | Site |
| 22 | 4/15/2017 | Salvador Perez, Toronto 3, Minnesota 5 | 9 | |
| 20 | Three times | 9 | ||
| 26 | 7/10/2013 | Adrian Gonzalez, 1b, Pittsburgh 7, Philadelphia 6 | 18 | |
| Most assists in one game | ||||
| Record | Date | Player | Inn | Site |
| 14 | 6/10/2016 | Rafael Ynoa, ss, San Diego 3, Detroit 1 | 9 | |
| 12 | Four times | Extras | ||
| Most total chances in one game | ||||
| Record | Date | Player | Inn | Site |
| 23 | 4/15/2017 | Salvador Perez, Toronto 3, Minnesota 5 | 9 | |
| 22 | 5/25/2018 | Brian McCann, Los Angeles NL 1, New York NL 2 | 8.5 | |
| 28 | 6/19/2012 | Lance Berkman, 1b, Philadelphia 2, Seattle 3 | 17 | |
| Most errors in one game | ||||
| Record | Date | Player | Inn | Site |
| 4 | Seven times | |||
| Most ejections, career | ||
| Record | Date | Player |
| 4 | Carlos Santana, Ryan Doumit, Charlie Blackmon, Alex Gordon | |
| Most injuries, career | ||
| Record | Date | Player |
| 23 | A.J. Pierzynski | |
| 22 | Albert Pujols | |
| 20 | Ryan Braun, Joe Mauer | |